ArticleProceedings of the National Academy of Sciences of the United States of America1989
Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 109 citations in OpenAlex.
- Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profiling.bioRxiv : the preprint server for biology · 2025Article
- Alternative Pharmacological Strategies for the Treatment of Alzheimer's Disease: Focus on Neuromodulator Function.Biomedicines · 2022Review
- Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain.Molecules (Basel, Switzerland) · 2021Review
- Aging is not equal across memory systems.Neurobiology of learning and memory · 2020Article
- Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.Translational psychiatry · 2018Article
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
- Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlClExperimental and therapeutic medicine · 2016Article
- Age-associated changes in hippocampal-dependent cognition in Diversity Outbred mice.Hippocampus · 2014Article
- Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.Translational psychiatry · 2013Article
- Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Spatial behavior and seizure-induced changes in c-fos mRNA expression in young and old rats.Neurobiology of aging · 2013Article
- Effects of rearing conditions on behaviour and endogenous opioids in rats with alcohol access during adolescence.PloS one · 2013Article
- Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.Alcohol (Fayetteville, N.Y.) · 2012Review
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Prominent hippocampal CA3 gene expression profile in neurocognitive aging.Neurobiology of aging · 2011Article
- Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.Addiction biology · 2011Article
- Age- and hormone-regulation of opioid peptides and synaptic proteins in the rat dorsal hippocampal formation.Brain research · 2011Article
- The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.Brain research · 2010Review
- Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Radioimmunoassay revealed increased dynorphin A(1-8)-like immunoreactivity [dynA(1-8)LI] in the aged rat brain. Among a number of brain regions examined, an age-related dynA(1-8)LI elevation was found only in the hippocampal formation and frontal cortex. Moreover, the increase in dynA(1-8)LI in the aged hippocampus was associated with a decline in spatial learning ability: dynA(1-8)LI distinguished aged rats that were behaviorally impaired from aged cohorts that learned the spatial task as rapidly as younger animals. Northern blot hybridization using a 32P-labeled complementary RNA probe encoding rat prodynorphin indicated that the abundance of prodynorphin mRNA was also significantly increased in the hippocampal formation of aged rats with identified spatial learning impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.