ArticlePeerJ2015
First genomic insights into members of a candidate bacterial phylum responsible for wastewater bulking.
Article in PeerJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 83 citations in OpenAlex.
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- Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.Nature communications · 2021Article
- Giant sulfur bacteria (Beggiatoaceae) from sediments underlying the Benguela upwelling system host diverse microbiomes.PloS one · 2021Article
- Database Mining to Unravel the Ecology of the Phylum Chloroflexi in Methanogenic Full Scale Bioreactors.Frontiers in microbiology · 2020Article
- Genomic and Physiological Characteristics of a Novel Nitrite-OxidizingFrontiers in microbiology · 2020Article
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- The Phylogeny, Biodiversity, and Ecology of theFrontiers in microbiology · 2019Review
- Genome Features and Secondary Metabolites Biosynthetic Potential of the ClassFrontiers in microbiology · 2019Article
- Uncovering the Uncultivated Majority in Antarctic Soils: Toward a Synergistic Approach.Frontiers in microbiology · 2019Review
- A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life.Nature biotechnology · 2018Article
- A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments.Microbiome · 2018Article
- Strategy to identify the causes and to solve a sludge granulation problem in methanogenic reactors: application to a full-scale plant treating cheese wastewater.Environmental science and pollution research international · 2018Article
- Molecular Docking Evaluation of (Molecules (Basel, Switzerland) · 2018Article
- New Biological Insights Into How Deforestation in Amazonia Affects Soil Microbial Communities Using Metagenomics and Metagenome-Assembled Genomes.Frontiers in microbiology · 2018Article
- Genomic Description of 'Frontiers in microbiology · 2018Article
- Metagenomics reveals niche partitioning within the phototrophic zone of a microbial mat.PloS one · 2018Article
- Recovery of nearly 8,000 metagenome-assembled genomes substantially expands the tree of life.Nature microbiology · 2017Article
- The impact of immigration on microbial community composition in full-scale anaerobic digesters.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous cells belonging to the candidate bacterial phylum KSB3 were previously identified as the causative agent of fatal filament overgrowth (bulking) in a high-rate industrial anaerobic wastewater treatment bioreactor. Here, we obtained near complete genomes from two KSB3 populations in the bioreactor, including the dominant bulking filament, using differential coverage binning of metagenomic data. Fluorescence in situ hybridization with 16S rRNA-targeted probes specific for the two populations confirmed that both are filamentous organisms. Genome-based metabolic reconstruction and microscopic observation of the KSB3 filaments in the presence of sugar gradients indicate that both filament types are Gram-negative, strictly anaerobic fermenters capable of non-flagellar based gliding motility, and have a strikingly large number of sensory and response regulator genes. We propose that the KSB3 filaments are highly sensitive to their surroundings and that cellular processes, including those causing bulking, are controlled by external stimuli. The obtained genomes lay the foundation for a more detailed understanding of environmental cues used by KSB3 filaments, which may lead to more robust treatment options to prevent bulking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.