ArticleNature communications2015
Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation.Cell reports methods · 2026Article
- Article
- KDM3A and KDM3B Maintain Naïve Pluripotency Through the Regulation of Alternative Splicing.bioRxiv : the preprint server for biology · 2024Article
- Metabolic control of induced pluripotency.Frontiers in cell and developmental biology · 2023Review
- Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.Stem cell reports · 2020Article
- Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity.The EMBO journal · 2019Article
- Defining Reprogramming Checkpoints from Single-Cell Analyses of Induced Pluripotency.Cell reports · 2019Article
- The role of α-ketoglutarate-dependent proteins in pluripotency acquisition and maintenance.The Journal of biological chemistry · 2019Review
- Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.Molecular metabolism · 2018Article
- Compartmentalization of HP1 Proteins in Pluripotency Acquisition and Maintenance.Stem cell reports · 2018Article
- Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.Stem cell reports · 2017Article
- Small molecules for reprogramming and transdifferentiation.Cellular and molecular life sciences : CMLS · 2017Review
- Chromatin module inference on cellular trajectories identifies key transition points and poised epigenetic states in diverse developmental processes.Genome research · 2017Article
- Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes.Genome research · 2017Article
- Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells.Cell reports · 2016Article
- PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.Stem cell reports · 2016Article
- Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications.Stem cell reviews and reports · 2016Review
- Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage.Stem cell reports · 2016Article
- Molecular features of cellular reprogramming and development.Nature reviews. Molecular cell biology · 2016Review
- Histone demethylases in chromatin biology and beyond.EMBO reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) represents a profound change in cell fate. Here, we show that combining ascorbic acid (AA) and 2i (MAP kinase and GSK inhibitors) increases the efficiency of reprogramming from fibroblasts and synergistically enhances conversion of partially reprogrammed intermediates to the iPSC state. AA and 2i induce differential transcriptional responses, each leading to the activation of specific pluripotency loci. A unique cohort of pluripotency genes including Esrrb require both stimuli for activation. Temporally, AA-dependent histone demethylase effects are important early, whereas Tet enzyme effects are required throughout the conversion. 2i function could partially be replaced by depletion of components of the epidermal growth factor (EGF) and insulin growth factor pathways, indicating that they act as barriers to reprogramming. Accordingly, reduction in the levels of the EGF receptor gene contributes to the activation of Esrrb. These results provide insight into the rewiring of the pluripotency network at the late stage of reprogramming.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.