Evidence map›Paper›PMID 25650098›Full record

ReviewAnnals of biomedical engineering2015

Scaffolds for tendon and ligament repair and regeneration.

Anthony Ratcliffe, David L Butler, Nathaniel A Dyment, Paul J Cagle, Christopher S Proctor, Seena S Ratcliffe, Evan L Flatow

Abstract readReview
In one paragraph

Review in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Woven solutions for tissue engineering: Next-generation heart valves from fiber to function.American heart journal plus : cardiology research and practice · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. A collagen/PLA hybrid scaffold supports tendon-derived cell growth for tendon repair and regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Ligament mechanics of ageing and osteoarthritic human knees.Frontiers in bioengineering and biotechnology · 2022
    Article
  18. Review
  19. A brief history of tendon and ligament bioreactors: Impact and future prospects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  20. The Role of Scaffolds in Tendon Tissue Engineering.Journal of functional biomaterials · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anthony RatcliffeSynthasome, Inc., 3030 Bunker Hill Street, Suite 308, San Diego, CA, 92109, USA, anthonyratcliffe@synthasome.com.
David L Butler
Nathaniel A Dyment
Paul J Cagle
Christopher S Proctor
Seena S Ratcliffe
Evan L Flatow

Funding

Skeletal, Craniofacial and Oral Biology Training GrantT90DE021989 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2011 to 2022
$4.5M
Tendon Response to In Vivo Fatigue DamageR01AR052743 · NIAMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI ANDARAWIS-PURI, NELLY · 2005 to 2015
$3.4M
A Developmentally-Based Tissue Engineering Approach to Improve Tendon RepairR01AR056943 · NIAMS · UNIVERSITY OF CINCINNATI · PI SHEARN, JASON T · 2009 to 2013
$3.3M
Human tendon stem progenitor cell aging and regenerationR01AG039561 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FLATOW, EVAN L, SUN, HUI BIN · 2012 to 2016
$2.5M
Assessing lineage decisions of musculoskeletal progenitor cells with agingR01AR054713 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROWE, DAVID W. · 2006 to 2010
$2.0M
STANDARD ANIMAL MODEL FOR ARTICULAR CARTILAGE REPAIRR44AR060032 · NIAMS · SYNTHASOME, INC. · PI RATCLIFFE, ANTHONY · 2012 to 2013
$1.6M
Adult Stem Cells: Osteoblast Differentiation and EngraftmentR01AR052374 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ROWE, DAVID W. · 2007 to 2011
$1.5M
NIAMS NIH HHS AR052374NIAMS NIH HHS AR052743NIAMS NIH HHS AR056943NIAMS NIH HHS AR54713NIAMS NIH HHS R01 AR052374NIAMS NIH HHS R01 AR052743NIAMS NIH HHS R01 AR054713NIAMS NIH HHS R01 AR056943NIAMS NIH HHS R44 AR060032NIAMS NIH HHS R44AR060032NIA NIH HHS AG039561NIA NIH HHS R01 AG039561NIDCR NIH HHS DE021989NIDCR NIH HHS T90 DE021989
6 · The paper itself

Abstract

Enhanced tendon and ligament repair would have a major impact on orthopedic surgery outcomes, resulting in reduced repair failures and repeat surgeries, more rapid return to function, and reduced health care costs. Scaffolds have been used for mechanical and biologic reinforcement of repair and regeneration with mixed results. This review summarizes efforts made using biologic and synthetic scaffolds using rotator cuff and ACL as examples of clinical applications, discusses recent advances that have shown promising clinical outcomes, and provides insight into future therapy.

Indexed as

RegenerationTissue ScaffoldsAnimalsHumansLigamentsTendons

Identifiers

PMID25650098
PMCPMC4380768

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.