ArticleScientific reports2015
Cellular imaging using temporally flickering nanoparticles.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Chip-based label-free incoherent super-resolution optical microscopy.Light, science & applications · 2025Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting.RSC advances · 2021Article
- Imaging of nanoparticle dynamics in live and apoptotic cells using temporally-modulated polarization.Scientific reports · 2019Article
- Improved Margins Detection of Regions Enriched with Gold Nanoparticles inside Biological Phantom.Materials (Basel, Switzerland) · 2017Article
- Three dimensional imaging of gold-nanoparticles tagged samples using phase retrieval with two focus planes.Scientific reports · 2015Article
- K-factor image deshadowing for three-dimensional fluorescence microscopy.Scientific reports · 2015Article
- Cellular superresolved imaging of multiple markers using temporally flickering nanoparticles.Scientific reports · 2015Article
- Superresolved labeling nanoscopy based on temporally flickering nanoparticles and the K-factor image deshadowing.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Utilizing the surface plasmon resonance effect in gold nanoparticles enables their use as contrast agents in a variety of applications for compound cellular imaging. However, most techniques suffer from poor signal to noise ratio (SNR) statistics due to high shot noise that is associated with low photon count in addition to high background noise. We demonstrate an effective way to improve the SNR, in particular when the inspected signal is indistinguishable in the given noisy environment. We excite the temporal flickering of the scattered light from gold nanoparticle that labels a biological sample. By preforming temporal spectral analysis of the received spatial image and by inspecting the proper spectral component corresponding to the modulation frequency, we separate the signal from the wide spread spectral noise (lock-in amplification).
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Registered trials
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