ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015
The human burst suppression electroencephalogram of deep hypothermia.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Changes in the Term Neonatal Electroencephalogram with General Anesthesia: A Systematic Review with Narrative Synthesis.Anesthesiology · 2024Pooled it
- Physiologic and anesthetic predictors of false-positive motor-evoked potential alerts during pediatric spine surgery.Spine deformity · 2026Article
- Electroencephalographic phenotypes of postoperative delirium in the perioperative period.Journal of anesthesia and translational medicine · 2026Review
- Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation.Intensive care medicine experimental · 2025Article
- Clinical Electroencephalography for Anesthesiologists and Intensivists: Part 2-Physiologic Signatures and Active Management.Anesthesiology · 2025Review
- Harvard Electroencephalography Database: A comprehensive clinical electroencephalographic resource from four Boston hospitals.Epilepsia · 2025Article
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- [Processed EEG for personalized dosing of anesthetics during general anesthesia].Die Anaesthesiologie · 2023Review
- Correlation between burst suppression and postoperative delirium in elderly patients: a prospective study.Aging clinical and experimental research · 2023Article
- Diversity of electroencephalographic patterns during propofol-induced burst suppression.Frontiers in systems neuroscience · 2023Article
- General anesthesia and sleep: like and unlike.Anesthesia and pain medicine · 2022Review
- Perioperative electroencephalography in cardiac surgery with hypothermic circulatory arrest: a narrative review.Interactive cardiovascular and thoracic surgery · 2022Review
- Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents.eLife · 2022Article
- Mitigation of perioperative neurocognitive disorders: A holistic approach.Frontiers in aging neuroscience · 2022Review
- Etiology of Burst Suppression EEG Patterns.Frontiers in psychology · 2021Article
- Burst Suppression During General Anesthesia and Postoperative Outcomes: Mini Review.Frontiers in systems neuroscience · 2021Review
- Network Model With Reduced Metabolic Rate Predicts Spatial Synchrony of Neuronal Activity.Frontiers in computational neuroscience · 2021Article
- Reducing Perioperative Neurocognitive Disorders (PND) Through Depth of Anesthesia Monitoring: A Critical Review.International journal of general medicine · 2021Review
- Independent Functional Outcomes after Prolonged Coma following Cardiac Arrest: A Mechanistic Hypothesis.Annals of neurology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveDeep hypothermia induces 'burst suppression' (BS), an electroencephalogram pattern with low-voltage 'suppressions' alternating with high-voltage 'bursts'. Current understanding of BS comes mainly from anesthesia studies, while hypothermia-induced BS has received little study. We set out to investigate the electroencephalogram changes induced by cooling the human brain through increasing depths of BS through isoelectricity.
methodsWe recorded scalp electroencephalograms from eleven patients undergoing deep hypothermia during cardiac surgery with complete circulatory arrest, and analyzed these using methods of spectral analysis.
resultsWithin patients, the depth of BS systematically depends on the depth of hypothermia, though responses vary between patients except at temperature extremes. With decreasing temperature, burst lengths increase, and burst amplitudes and lengths decrease, while the spectral content of bursts remains constant.
conclusionsThese findings support an existing theoretical model in which the common mechanism of burst suppression across diverse etiologies is the cyclical diffuse depletion of metabolic resources, and suggest the new hypothesis of local micro-network dropout to explain decreasing burst amplitudes at lower temperatures. SIGNIFICANCE: These results pave the way for accurate noninvasive tracking of brain metabolic state during surgical procedures under deep hypothermia, and suggest new testable predictions about the network mechanisms underlying burst suppression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.