ArticleNeuroinformatics2015
Impact of Early and Late Visual Deprivation on the Structure of the Corpus Callosum: A Study Combining Thickness Profile with Surface Tensor-Based Morphometry.
Article in Neuroinformatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration.The American journal of pathology · 2025Review
- Surface-based morphometry of the corpus callosum in young children of ages 1-5.Human brain mapping · 2024Article
- Tetrahedral spectral feature-Based bayesian manifold learning for grey matter morphometry: Findings from the Alzheimer's disease neuroimaging initiative.Medical image analysis · 2021Article
- The effect of congenital blindness on resting-state functional connectivity revisited.Scientific reports · 2021Observational
- Brain-Machine Interfaces to Assist the Blind.Frontiers in human neuroscience · 2021Review
- Neurocranium thickness mapping in early childhood.Scientific reports · 2020Article
- Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.Brain and behavior · 2020Article
- Differences in the major fiber-tracts of people with congenital and acquired blindness.IS&T International Symposium on Electronic Imaging · 2020Article
- Cranial thickness changes in early childhood.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Emotion processing in early blind and sighted individuals.Neuropsychology · 2017Article
- Altered microstructure rather than morphology in the corpus callosum after lower limb amputation.Scientific reports · 2017Article
- Concurrent decrease of brain white matter tracts' thicknesses and fractional anisotropy after antenatal hypoxia-ischemia detected with tract-based spatial statistics analysis.Journal of magnetic resonance imaging : JMRI · 2017Article
- Towards a Holistic Cortical Thickness Descriptor: Heat Kernel-Based Grey Matter Morphology Signatures.NeuroImage · 2017Article
- Shape Analysis with Hyperbolic Wasserstein Distance.Proceedings. IEEE Computer Society Conference on Computer Vision and Pattern Recognition · 2016Article
- In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT.Investigative ophthalmology & visual science · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Blindness represents a unique model to study how visual experience may shape the development of brain organization. Exploring how the structure of the corpus callosum (CC) reorganizes ensuing visual deprivation is of particular interest due to its important functional implication in vision (e.g., via the splenium of the CC). Moreover, comparing early versus late visually deprived individuals has the potential to unravel the existence of a sensitive period for reshaping the CC structure. Here, we develop a novel framework to capture a complete set of shape differences in the CC between congenitally blind (CB), late blind (LB) and sighted control (SC) groups. The CCs were manually segmented from T1-weighted brain MRI and modeled by 3D tetrahedral meshes. We statistically compared the combination of local area and thickness at each point between subject groups. Differences in area are found using surface tensor-based morphometry; thickness is estimated by tracing the streamlines in the volumetric harmonic field. Group differences were assessed on this combined measure using Hotelling's T(2) test. Interestingly, we observed that the total callosal volume did not differ between the groups. However, our fine-grained analysis reveals significant differences mostly localized around the splenium areas between both blind groups and the sighted group (general effects of blindness) and, importantly, specific dissimilarities between the LB and CB groups, illustrating the existence of a sensitive period for reorganization. The new multivariate statistics also gave better effect sizes for detecting morphometric differences, relative to other statistics. They may boost statistical power for CC morphometric analyses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.