Observational studyJournal of cardiothoracic and vascular anesthesia2015
Plasma corin decreases after coronary artery bypass graft surgery and is associated with postoperative heart failure: a pilot study.
Observational study in Journal of cardiothoracic and vascular anesthesia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01258231 (Identification of Genomic Predictors of Adverse Events After Cardiac Surgery), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.Circulation · 2020Pooled it
- Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).ARYA atherosclerosis · 2025Review
- Falling corin and ANP activity levels accelerate development of heart failure and cardiac fibrosis.Frontiers in cardiovascular medicine · 2023Article
- Impact of high intensity interval and moderate continuous training on plasma ratios of ProBNPFrontiers in physiology · 2023Article
- Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity.Journal of the American Heart Association · 2022Article
- Low serum corin levels predict end-organ damage in patients with hypertensive crisis.Anatolian journal of cardiology · 2021Article
- Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.International journal of molecular sciences · 2020Article
- Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy.International journal of molecular sciences · 2019Article
- Sex-specific association between soluble corin and metabolic syndrome in Chinese adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography.PloS one · 2019Article
- Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury.PloS one · 2018Article
- Identification and functional analysis of CORIN variants in hypertensive patients.Human mutation · 2017Article
- Potential value of circulating corin levels in acute and chronic myocardial infarction.Journal of laboratory and precision medicine · 2017Article
- Role of corin in the regulation of blood pressure.Current opinion in nephrology and hypertension · 2017Review
- Depressed Corin Levels Indicate Early Systolic Dysfunction Before Increases of Atrial Natriuretic Peptide/B-Type Natriuretic Peptide and Heart Failure Development.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy.Cardiovascular diabetology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveCorin is a natriuretic peptide-converting enzyme that cleaves precursor pro-B-type natriuretic peptide to active B-type natriuretic peptide (BNP) (diuretic, natriuretic, and vasodilatory properties). Increased plasma BNP is a known diagnostic and prognostic heart failure (HF) biomarker in ambulatory and surgical patients. Recent studies indicate that plasma corin is decreased significantly in chronic HF patients, yet perioperative plasma corin concentrations have not been assessed in cardiac surgical patients. The objectives of this study were to determine the effect of coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) on plasma corin concentrations and to assess the association between change in perioperative plasma corin concentration and long-term postoperative HF hospitalization or death. It was hypothesized that plasma corin concentrations decrease significantly from preoperative baseline during postoperative days 1 to 4 and that hospitalization or death from HF during the 5 years after surgery is associated with higher relative difference (preoperative baseline to postoperative nadir) in plasma corin concentrations.
designProspective observational pilot study.
settingTwo institutions: Brigham and Women's Hospital, Boston, Massachusetts and the Texas Heart Institute, St. Luke's Hospital, Houston, Texas.
participants99 patients of European ancestry who underwent isolated primary CABG surgery with CPB.
interventionsNonemergency isolated primary CABG surgery with CPB. MEASUREMENTS AND MAIN
resultsPlasma corin concentration was assessed preoperatively and at 4 postoperative time points (postoperative days 1-4). HF hospitalization or HF death events during the 5 years after surgery were identified by review of hospital and death records. Postoperative plasma corin concentrations were significantly lower than preoperative baseline concentrations (p<0.0001). Perioperative corin concentrations were significantly higher in males than in females (p<0.0001). Fifteen patients experienced long-term postoperative HF events. Patients who experienced HF hospitalization or HF death during study follow-up had significantly higher relative difference in plasma corin concentration (preoperative baseline to postoperative nadir) than patients who did not experience HF events during study follow-up (p=0.03).
conclusionsPlasma corin concentrations decrease significantly from preoperative concentrations after CABG surgery. HF hospitalization or HF death during the 5 years after CABG surgery with CPB is associated with larger relative decrease in plasma corin concentration from preoperative baseline. Further investigation is warranted to determine the role of corin in postoperative HF biology.
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