ArticleJournal of aging and health2015
Inflammation Partially Mediates the Association of Multimorbidity and Functional Limitations in a National Sample of Middle-Aged and Older Adults: The MIDUS Study.
Article in Journal of aging and health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Identifying risk factors for in-stent restenosis in symptomatic intracranial atherosclerotic stenosis: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Who's at risk for emergent depression years later? Predictive modeling in a nine-year longitudinal cohort.BMC psychiatry · 2026Article
- Childhood SES gradients in adult functional limitations: Does state-level macro-economic context matter?Social science & medicine (1982) · 2025Article
- A novel DNA methylation-based surrogate biomarker for chronic systemic inflammation (Inflammation Latent Variable Methylation Surrogate, InfLaMeS).The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Impact of muscle strength decline and exercise intervention on multimorbidity of chronic diseases in older adults.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Boosting Immunity Through Nutrition and Gut Health: A Narrative Review on Managing Allergies and Multimorbidity.Nutrients · 2025Review
- Associations between the risk of LUTS/BPH and the number and class of chronic diseases among middle-aged and elder men.Scientific reports · 2025Article
- Evaluation of Joint Effect of Frailty and Sleep Health on Cardiometabolic Multimorbidity in Aging Population.Nature and science of sleep · 2025Article
- Systemic inflammation in midlife is associated with late-life functional limitations.Scientific reports · 2024Observational
- The Association Between Inflammatory Dietary Pattern and Risk of Cognitive Impairment Among Older Adults with Chronic Diseases and Its Multimorbidity: A Cross-Sectional Study.Clinical interventions in aging · 2024Article
- Prevalence of multiple long-term chronic conditions and associated disabilities among community-dwelling adults in Riyadh.Frontiers in public health · 2024Article
- Biological age and brain age in midlife: relationship to multimorbidity and mental health.Neurobiology of aging · 2023Article
- Smoking may compromise physical function long before it kills you.Frontiers in public health · 2023Article
- Work-family enrichment: A potential buffer of inflammation among black adults?Brain, behavior, & immunity - health · 2022Article
- Inflammatory biomarkers, multi-morbidity, and biologic aging.The Journal of international medical research · 2022Article
- Multiple Chronic Diseases Associated With Tooth Loss Among the US Adult Population.Frontiers in big data · 2022Article
- Blood biomarkers of progressive atherosclerosis and restenosis after stenting of symptomatic intracranial artery stenosis.Scientific reports · 2021Article
- Longitudinal relationship of diabetes and depressive symptoms in older adults from Mexico: a secondary data analysis.BMJ open diabetes research & care · 2020Article
- Multimorbidity, Function, and Cognition in Aging.Clinics in geriatric medicine · 2020Review
- Measuring biological aging in humans: A quest.Aging cell · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOlder adults are increasingly likely to have two or more chronic medical conditions (multimorbidity) and are consequently at greater risk of disability. Here we examine the role of inflammation in mediating the relationship between multimorbidity and disability.
methodData are from the Survey of Mid-Life in the United States (MIDUS), a national sample of middle-aged and older adults. Structural equation models were used to assess direct relationships between multimorbidity and activities of daily living as well as indirect associations with a latent variable for inflammation (indicated by circulating levels of interleukin-6, C-reactive protein, and fibrinogen) as a mediator.
resultsAfter adjustment for potential confounds, multimorbidity was positively associated with inflammation (p < .001) and functional limitations (p < .001), and inflammation partially mediated the link between multimorbidity and functional limitations (p < .01). DISCUSSION: Inflammation may be an important biological mechanism through which chronic medical conditions are linked to disability in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.