ArticleClinical and experimental vaccine research2015
In silico analysis for identifying potential vaccine candidates against Staphylococcus aureus.
Article in Clinical and experimental vaccine research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Bacterial mutation dynamics emerging insights into virulence evolution and drug resistance. A review study.Frontiers in medicine · 2026Review
- Molecular and Immunological Properties of a Chimeric Glycosyl Hydrolase 18 Based on Immunoinformatics Approaches: A Design of a New Anti-ACS pharmacology & translational science · 2025Article
- A multi-epitope vaccine targeting a key virulence factor ClfA: An In-silico approach to combat Staphylococcus aureus infections.PloS one · 2025Article
- Immunoinformatic prediction to identifyVeterinary world · 2024Article
- Article
- Development of a candidate multi-epitope vaccine againstSaudi medical journal · 2023Article
- Protocol for a scoping review of potential vaccine candidates predicted by VaxiJen for different viral pathogens between 2017-2021.Systematic reviews · 2022Article
- Engineering a multi epitope vaccine against SARS-CoV-2 by exploiting its non structural and structural proteins.Journal of biomolecular structure & dynamics · 2022Article
- In Silico Prediction of a Multitope Vaccine againstVaccines · 2021Article
- Identification of CD4Biotechnologia · 2021Article
- The Recombinant Expression Proteins FnBP and ClfA FromFrontiers in veterinary science · 2021Article
- In silico analysis of epitope-based CadF vaccine design against Campylobacter jejuni.BMC research notes · 2020Article
- Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum.BMC bioinformatics · 2019Article
- iTRAQ-Based Quantitative Proteomic Profiling ofFrontiers in microbiology · 2019Article
- Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design.Pathogens and global health · 2018Article
- Construction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunity.Immunologic research · 2016Article
- Breaking the Spell: Combating Multidrug Resistant 'Superbugs'.Frontiers in microbiology · 2016Review
- A potent multivalent vaccine for modulation of immune system in atherosclerosis: an in silico approach.Clinical and experimental vaccine research · 2016Article
- Systemic Approach to Virulence Gene Network Analysis for Gaining New Insight into Cryptococcal Virulence.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStaphylococcus aureus is one of the most important causes of nosocomial and community-acquired infections. The increasing incidence of multiple antibiotic-resistant S. aureus strains and the emergence of vancomycin resistant S. aureus strains have placed renewed interest on alternative means of prevention and control of infection. S. aureus produces a variety of virulence factors, so a multi-subunit vaccine will be more successful for preventing S. aureus infections than a mono-subunit vaccine. MATERIALS AND
methodsWe selected three important virulence factors of S. aureus, clumping factor A (ClfA), iron-regulated surface determinant (IsdB), and gamma hemolysin (Hlg) that are potential candidates for vaccine development. We designed synthetic genes encoding the clfA, isdB, and hlg and used bioinformatics tools to predict structure of the synthetic construct and its stabilities. VaxiJen analysis of the protein showed a high antigenicity. Linear and conformational B-cell epitopes were identified.
resultsThe proteins encoded by these genes were useful as vaccine candidates against S. aureus infections.
conclusionIn silico tools are highly suited to study, design, and evaluate vaccine strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.