Evidence map›Paper›PMID 25649538›Full record

ReviewSurgery today2016

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi, Toshihiko Torigoe, Fukino Satomi, Hiroaki Shima, Goro Kutomi, Shigenori Ota, Masayuki Ishii, Hiroshi Hayashi, Sumiyo Asakura, Yoshihiko Hirohashi and 9 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Toru MizuguchiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan. tmizu@sapmed.ac.jp.
Toshihiko TorigoeDepartment of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Fukino SatomiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Hiroaki ShimaDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Goro KutomiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Shigenori OtaDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Masayuki IshiiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Hiroshi HayashiDepartment of TR Management, Hokkaido Organization for Translational Research, Hokkaido University, Sapporo, Hokkaido, 060-8638, Japan.
Sumiyo AsakuraDepartment of Public Health, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Yoshihiko HirohashiDepartment of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Makoto MeguroDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Yasutoshi KimuraDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Toshihiko NishidateDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Kenji OkitaDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Masaho IshinoDepartment of Intellectual Property Management Office, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Atsushi MiyamotoDepartment of Hospital Pharmacy, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Masamitsu HatakenakaDepartment of Diagnostic Radiology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Noriyuki SatoDepartment of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Koichi HirataDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido 060-8543, Japan.
Sapporo Medical University · JPHokkaido University · JPSapporo Medical University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors.

Indexed as

Bacterial VaccinesCancer VaccinesCarcinoembryonic AntigenCarcinoma, Pancreatic DuctalClinical Trials as TopicFowlpox virusGastrinsGenes, rasHeat-Shock ProteinsInhibitor of Apoptosis ProteinsKinesinsListeria monocytogenesMucin-1MutationPancreatic NeoplasmsPeptidesBacterial VaccinesBIRC5 protein, humanCancer VaccinesCarcinoembryonic Antigengastrin immunogenGastrinsGVAX vaccineHeat-Shock ProteinsInhibitor of Apoptosis ProteinsKDR protein, humanKIF20A protein, humanKinesinsMUC1 protein, humanMucin-1PeptidesSurvivinTelomeraseTERT protein, humanVaccines, AttenuatedVascular Endothelial Growth Factor Receptor-2Viral VaccinesWT1 protein, humanWT1 ProteinsImmunomodulationPancreatic cancerVaccine

Identifiers

PMID25649538
OpenAlexW2012188049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.