Evidence map›Paper›PMID 25649528›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2015

Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.

Tyson J Moyer, Hussein A Kassam, Edward S M Bahnson, Courtney E Morgan, Faifan Tantakitti, Teng L Chew, Melina R Kibbe, Samuel I Stupp

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. ATP-Regulated Formation of Transient Peptide Amphiphiles Superstructures.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  5. Review
  6. Article
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  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tyson J MoyerSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Hussein A KassamSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Edward S M BahnsonSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Courtney E MorganSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Faifan TantakittiSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Teng L ChewSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Melina R KibbeSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.
Samuel I StuppSimpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.

Funding

Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Novel Vehicles for Targeted Cardiovascular RepairR01HL116577 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KIBBE, MELINA RAE, STUPP, SAMUEL I · 2013 to 2016
$4.3M
Vascular Surgery Scientist Training ProgramT32HL094293 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ESKANDARI, MARK K · 2009 to 2023
$4.0M
NCATS NIH HHS UL1 TR000150NCATS NIH HHS UL1TR000150NHLBI NIH HHS 1R01HL116577-01NHLBI NIH HHS R01 HL116577NHLBI NIH HHS T32 HL094293NHLBI NIH HHS T32HL094293
6 · The paper itself

Abstract

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.

Indexed as

AnimalsCarotid Artery InjuriesMacromolecular SubstancesMaleNanoparticlesParticle SizePeptidesRatsRats, Sprague-DawleySurface-Active AgentsTreatment OutcomeMacromolecular SubstancesPeptidesSurface-Active Agentspeptidesself-assemblysupramolecular chemistryvascular targeting

Identifiers

PMID25649528
PMCPMC4478239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.