ArticleMedical gas research2015
Stimulation of human damaged sperm motility with hydrogen molecule.
Article in Medical gas research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.Oxidative medicine and cellular longevity · 2021Review
- Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice.Chinese journal of integrative medicine · 2020Article
- Melatonin Inhibits Formation of Mitochondrial Permeability Transition Pores and Improves Oxidative Phosphorylation of Frozen-Thawed Ram Sperm.Frontiers in endocrinology · 2019Article
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- Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters.BMC genomics · 2018Article
- EFFECT OF YISHENJIANPI RECIPE ON SEMEN QUALITY AND SPERM MITOCHONDRIA IN MICE WITH OLIGOASTHENOZOOSPERMIA INDUCED BY TRIPTERYGIUM GLYCOSIDES.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida 3.Chinese medical journal · 2016Article
- Hydrogen therapy: from mechanism to cerebral diseases.Medical gas research · 2016Review
- New Beginnings forMedical gas research · 2016Article
- Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism.NPJ aging and mechanisms of disease · 2016Article
- Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.Medical gas research · 2015Article
- What's new inMedical gas researchArticle
- The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease.Medical gas researchArticle
- The role of hydrogen sulfide in stroke.Medical gas researchReview
- Molecular hydrogen: a therapeutic antioxidant and beyond.Medical gas researchReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSperm motility is a critical factor in male fertility. Low motility can be caused by a variety factors including abnormal spermatogenesis, oxidative damage, or depletion of intracellular ATP. Recent findings indicate that hydrogen molecule (H2) selectively reduces toxic reactive oxygen species. In this study, we investigated the effects of H2 on human sperm motility in vitro.
methodsExperimentally damaged sperm suspensions from patients left at room temperature for > 5 days or frozen immediately after ejaculation were used. After exposure with H2, their forward motility was measured with a counting chamber. A time-lapse movie was recorded to analyze sperm swimming speed. Mitochondria were stained with a membrane potential-sensitive dye.
resultsH2 treatment significantly improved the rate of forward motility, whereas treatment with nitrogen gas did not. While treatment for 30 min was sufficient to improve motility, it did not affect sperm swimming speed. After 24 h, retreatment with H2 increased the motility again. H2 treatment also increased mitochondrial membrane potential. Forward motility of low motile frozen-thawed sperm from patients significantly improved with cleavage medium containing H2.
conclusionsOur results illustrated that H2 treatment stimulates low sperm motility. H2 is a new promising tool for male infertility treatments.
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