ArticleJournal of assisted reproduction and genetics2015
Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome.
Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genetic association between LHCGR variants and polycystic ovary syndrome: a meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Polymorphisms in FSHR modulating susceptibility to polycystic ovary syndrome: an updated meta-analysis.Journal of ovarian research · 2023Pooled it
- A Comprehensive Overview of Common Polymorphic Variants in Genes Related to Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2021Pooled it
- Exploring genotype-phenotype correlation of FSHR polymorphisms in polycystic ovary syndrome.BMC endocrine disorders · 2025Article
- Susceptibility loci identified in Han Chinese influence genetic predisposition of PCOS in Indian women.Molecular biology reports · 2024Article
- Significance of LHCGR polymorphisms in polycystic ovary syndrome: an association study.Scientific reports · 2023Article
- Effect Modification of LHCGR Gene Variant (rs2293275) on Clinico-Biochemical Profile, and Levels of Luteinizing Hormone in Polycystic Ovary Syndrome Patients.Biochemical genetics · 2023Article
- Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Molecular Role of Asn680Ser and Asp37Glu Missense Variants in Saudi Women with Female Infertility and Polycystic Ovarian Syndrome.Current issues in molecular biology · 2023Article
- Article
- Association analysis of LHCGR variants and polycystic ovary syndrome in Punjab: a case-control approach.BMC endocrine disorders · 2022Article
- Assessment ofHeliyon · 2022Article
- Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS).Frontiers in endocrinology · 2019Review
- Pathophysiological mechanisms of gonadotropins- and steroid hormones-related genes in etiology of polycystic ovary syndrome.Iranian journal of basic medical sciences · 2019Review
- Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.Endocrinology · 2018Article
- FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome.Journal of assisted reproduction and genetics · 2017Article
- Effect of Follicle Stimulating Hormone Receptor Gene Polymorphisms in Cervical Cancer Risk.Pathology oncology research : POR · 2017Article
- Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.Scientific reports · 2015Article
- An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options.Women's health (London, England)Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious studies identified follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) genes as polycystic ovary syndrome (PCOS) susceptibility loci, which was dependent on the racial/ethnic background of studied population. We investigated the association of genetic variants in FSHR and LHCGR with PCOS in Bahraini Arab women.
methodsA retrospective case-control study, involving 203 women with PCOS, and 211 age- and ethnically-matched control women. FSHR and LHCGR genotyping was done by allelic exclusion method (real-time PCR).
resultsSignificantly lower frequencies of heterozygous LHCGR rs7371084 and FSHR rs11692782 genotype carriers were seen between women with PCOS vs. controls, and increased frequency of heterozygous homozygous LHCGR rs4953616 genotype carriers were detected between women with PCOS compared to control women. Limited linkage disequilibrium was noted among LHCGR and FSHR SNPs, and 2 blocks were constructed: the first (Block 1) spanning 61 kb contained the six tested LHCGR SNPs, and the second (Block 2) spanning 298 kb contained four of the five tested FSHR SNPs. Higher frequency of LHCGR GTCAAG haplotype was seen in women with PCOS compared to controls; the frequencies of the remaining LHCGR haplotypes, and all FSHR haplotypes were similar between cases and controls.
conclusionThis is the first study to confirm the association of novel LHCGR (rs7371084, rs4953616) and FSHR (rs11692782) SNPs with PCOS. The differential association of LHCGR and FSHR variants with PCOS confirms the racial/ethnic contribution to their association with PCOS.
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