ArticleTranslational stroke research2015
Iron-induced necrotic brain cell death in rats with different aerobic capacity.
Article in Translational stroke research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Inhaled Anesthetics: Beyond the Operating Room.Journal of clinical medicine · 2024Review
- Neurovascular Units and Neural-Glia Networks in Intracerebral Hemorrhage: from Mechanisms to Translation.Translational stroke research · 2021Review
- The role of complement in brain injury following intracerebral hemorrhage: A review.Experimental neurology · 2021Review
- Hydrocephalus Following Experimental Subarachnoid Hemorrhage in Rats with Different Aerobic Capacity.International journal of molecular sciences · 2021Article
- Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage.Frontiers in pharmacology · 2021Article
- Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets.Experimental neurology · 2019Review
- Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury.Translational stroke research · 2019Article
- An Update On Medical Treatment for Intracerebral Hemorrhage.Translational stroke research · 2018Article
- P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke.Current neuropharmacology · 2018Review
- Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36.Translational stroke research · 2017Article
- Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.Translational stroke research · 2017Article
- MRI Characterization in the Acute Phase of Experimental Subarachnoid Hemorrhage.Translational stroke research · 2017Article
- Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage.Translational stroke research · 2017Article
- Neuro-regeneration therapy using human Muse cells is highly effective in a mouse intracerebral hemorrhage model.Experimental brain research · 2017Article
- Predictive Value of CTA Spot Sign on Hematoma Expansion in Intracerebral Hemorrhage Patients.BioMed research international · 2017Review
- Microglia Activation and Polarization After Intracerebral Hemorrhage in Mice: the Role of Protease-Activated Receptor-1.Translational stroke research · 2016Article
- Article
- Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets.Translational stroke research · 2016Review
- Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy.PloS one · 2015Article
- Paradigms and mechanisms of inhalational anesthetics mediated neuroprotection against cerebral ischemic stroke.Medical gas researchReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Brain iron overload has a key role in brain injury after intracerebral hemorrhage (ICH). Our recent study demonstrated that ICH-induced brain injury was greater in low capacity runner (LCR) than in high capacity runner (HCR) rats. The present study examines whether iron-induced brain injury differs between LCRs and HCRs. Adult male LCR and HCR rats had an intracaudate injection of iron or saline. Rats were euthanized at 2 and at 24 h after T2 magnetic resonance imaging, and the brains were used for immunostaining and Western blotting. LCRs had more hemispheric swelling, T2 lesion volumes, blood-brain barrier disruption, and neuronal death at 24 h after iron injection (p < 0.05). Many propidium iodide (PI)-positive cells, indicative of necrotic cell death, were observed in the ipsilateral basal ganglia of both HCRs and LCRs at 2 h after iron injection. PI fluorescence intensity was higher in LCRs than in HCRs. In addition, membrane attack complex (MAC) expression was increased at 2 h after iron injection and was higher in LCRs than in HCRs. The PI-positive cells co-localized with MAC-positive cells in the ipsilateral basal ganglia. Iron induces more severe necrotic brain cell death, brain swelling, and blood-brain barrier disruption in LCR rats, which may be related with complement activation and MAC formation.
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