ArticleParasites & vectors2015
Leishmania tarentolae molecular signatures in a 300 hundred-years-old human Brazilian mummy.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Partners in time: Cospeciation and host-switching shape the evolution of Leishmania parasites.PLoS neglected tropical diseases · 2025Article
- Beyond reptiles: the fire salamander as a potential host forInternational journal for parasitology. Parasites and wildlife · 2025Article
- UnveilingInternational journal for parasitology. Parasites and wildlife · 2025Article
- Epidemiological dynamics ofMicrobial genomics · 2025Article
- Sand Fly Fauna and Prevalence ofTransboundary and emerging diseases · 2025Article
- hsp70 PCR-RFLP as an alternative tool to identify Sauroleishmania species.Parasitology research · 2024Article
- Wildlife parasitology: sample collection and processing, diagnostic constraints, and methodological challenges in terrestrial carnivores.Parasites & vectors · 2024Review
- Leishmania tarentolae: a vaccine platform to target dendritic cells and a surrogate pathogen for next generation vaccine research in leishmaniases and viral infections.Parasites & vectors · 2023Review
- Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases.Transboundary and emerging diseases · 2022Review
- Development of VariousMicroorganisms · 2021Article
- Detection of Leishmania tarentolae in lizards, sand flies and dogs in southern Italy, where Leishmania infantum is endemic: hindrances and opportunities.Parasites & vectors · 2021Article
- Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy.PLoS neglected tropical diseases · 2021Article
- Reptile vector-borne diseases of zoonotic concern.International journal for parasitology. Parasites and wildlife · 2021Review
- Dipeptidyl peptidase III as a DNA marker to investigate epidemiology and taxonomy of Old World Leishmania species.PLoS neglected tropical diseases · 2021Article
- Techniques to study phagocytosis and uptake of Leishmania tarentolae by J774 macrophages.Experimental parasitology · 2019Article
- Preparation of transgenic Iranian lizard Leishmania coding HIL-12.Iranian journal of microbiology · 2017Article
- The genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania.Scientific reports · 2017Article
- The Paleoparasitology in Brazil and Findings in Human Remains from South America: A Review.The Korean journal of parasitology · 2016Review
- Ecological scenario and Trypanosoma cruzi DTU characterization of a fatal acute Chagas disease case transmitted orally (Espírito Santo state, Brazil).Parasites & vectors · 2016Article
- First molecular detection of Leishmania tarentolae-like DNA in Sergentomyia minuta in Spain.Parasitology research · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundL. tarentolae, the lizard-infecting species of Old World geckos, has been classified as non-pathogenic to man. While it has been demonstrated that L. tarentolae is capable of infecting human phagocytic cells and to differentiate into amastigote-like forms, there is no clear evidence for its efficient replication within macrophages. Here we provide first evidence for L. tarentolae ancient DNA sequences from bone marrow and intestines of a 300yo adult male.
methodsWe identified molecular signatures of Leishmania tarentolae, the lizard-infecting species of Old World geckos, in hard and soft tissue biopsies from a Brazilian mummy (A74) uncovered in Itacambira (Brazil) and dating to the Colonial Period (end of 18th/beginning of the 19th century).
resultsOur results imply that efficient replication of the parasite occurred within human macrophage and to lead to a systemic spread and visceralization in this individual. The ancient sequences show a 100% similarity with those of isolated L. tarentolae parasites grown on artificial nutrient media and a 99% similarity with two modern sequences isolated from reptiles.
conclusionsDe facto, our findings re-open the debate about the potential survival of ancient L. tarentolae strain within human macrophage and its ability to spread systemically. They also raise ecological issues since it is unknown whether this parasite circulates in the reptilian reservoir in modern day Brazil or not. Investigations on fossil fauna and arthropods are needed to shed light on the interactions between saurian Leishmania and lizards in Brazil's remote and recent past.
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