Evidence map›Paper›PMID 25648963›Full record

ArticleBiological psychiatry2015

Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

Stéphanie Debette, Carla A Ibrahim Verbaas, Jan Bressler, Maaike Schuur, Albert Smith, Joshua C Bis, Gail Davies, Christiane Wolf, Vilmundur Gudnason, Lori B Chibnik and 116 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 7 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 7 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
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  16. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

126 authors at 20 institutions in 12 countries.

Stéphanie DebetteDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; Institut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux; Department of Neurology, University Hospital of Bordeaux, Bordeaux, France. Electronic address: sdebette@bu.edu.
Carla A Ibrahim VerbaasGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas.
Maaike SchuurGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Albert SmithIcelandic Heart Association, Kopavogur; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Department of Psychology, The University of Edinburgh; Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Christiane WolfMax Planck Institute of Psychiatry, Munich, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Lori B ChibnikProgram in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Anita L deStefanoDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Dominique J F de QuervainPsychiatric University Clinics and Department of Psychology, Division of Cognitive Neuroscience, University of Basel, Basel, Switzerland.
Velandai SrikanthStroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia.
Jari LahtiInstitute of Behavioural Sciences, University of Helsinki; Folkhälsan Research Centre, Helsinki, Finland.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund; German Center for Neurodegenerative Diseases, Site Rostock/ Greifswald, Rostock, Germany.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Lutz PriebeInstitute of Human Genetics, Universitätsklinikum Bonn, Bonn, Germany.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
Nazanin KarbalaiMax Planck Institute of Psychiatry, Munich, Germany.
Caroline HaywardMedical Research Council Human Genetics Unit.
James F WilsonInstitute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom, Centre for Population Health Sciences, University of Edinburgh, United Kingdom.
Harry CampbellDivision of General Neurology, Department of Neurology, Medical University and General Hospital of Graz, Austria.
Katja PetrovicDivision of General Neurology, Department of Neurology, Medical University and General Hospital of Graz, Austria.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas; Institute of Molecular Medicine, University of Texas-Houston Health Science Center, Houston, Texas.
Ganesh ChauhanInstitut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux.
Robin YeoInstitut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux.
Ruth BoxallCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh.
James BeckerDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Oliver StegleMax Planck Institute for Intelligent Systems, Tübingen, Germany; Max Planck Institute for Developmental Biology, Tübingen, Germany.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, University of New South Wales, Sydney, Australia.
Vincent ChourakiInstitut National de la Santé et de la Recherche Médicale Unit 744, Institut Pasteur de Lille, and Université Lille Nord de France, Lille, France.
Qi SunDepartment of Nutrition, Harvard School of Public Health; Channing Division of Network Medicine, Department of Medicine, Brigham and Women׳s Hospital and Harvard Medical School; Harvard Medical School, Brigham and Women׳s Hospital, Boston, Massachusetts.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women׳s Hospital, Boston, Massachusetts.
Susan ResnickBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Christopher OldmeadowCentre for Clinical Epidemiology and Biostatistics, School of Medicine, Newcastle, Australia; Public Health, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.
Mirna KirinInstitute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom, Centre for Population Health Sciences, University of Edinburgh, United Kingdom.
Alan F WrightInstitute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom, Centre for Population Health Sciences, University of Edinburgh, United Kingdom.
Maria K JonsdottirIcelandic Heart Association, Kopavogur.
Rhoda AuDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Albert BeckerInstitute of Neuropathology, Universitätsklinikum Bonn, Bonn, Germany.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Mike A NallsMolecular Genetics Section , Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Stephen T TurnerDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
Ben OostraGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Department of Clinical Genetics, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Gwen WindhamDepartment of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, Mississippi.
Laura H CokerDivision of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Gerardo HeissDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Michael E GriswoldCenter of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, Mississippi.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Veronique VitartMedical Research Council Human Genetics Unit.
Nicholas D HastieMedical Research Council Human Genetics Unit.
Lina ZgagaMedical Research Council Human Genetics Unit.
Igor RudanInstitute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom, Centre for Population Health Sciences, University of Edinburgh, United Kingdom.
Ozren PolasekDepartment of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Elizabeth G HollidayCentre for Clinical Epidemiology and Biostatistics, School of Medicine, Newcastle, Australia.
Peter SchofieldCentre for Clinical Epidemiology and Biostatistics, School of Medicine, Newcastle, Australia; Department of Medicine, John Hunter Hospital, Newcastle, Australia.
Seung Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston.
Toshiko TanakaLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Yang AnBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
Rodney T PerryDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Richard E KennedyDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama.
Michèle M SaleCenter for Public Health Genomics, Department of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia.
Jing WangDepartment of Biostatistics, Boston University School of Public Health, Boston.
Virginia G WadleyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Department of Psychology, The University of Edinburgh.
Paul M RidkerHarvard Medical School, Brigham and Women׳s Hospital, Boston, Massachusetts; Division of Preventive Medicine, Brigham and Women׳s Hospital, Boston, Massachusetts.
Alan J GowCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Department of Psychology, The University of Edinburgh.
Alison PattieCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom.
David PorteousCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Xuan LiuDepartment of Biostatistics, Boston University School of Public Health, Boston.
Russell ThomsonMenzies Research Institute Tasmania, University of Tasmania, Hobart, Australia.
Nicola J ArmstrongCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, University of New South Wales, Sydney, Australia; Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst; School of Mathematics & Statistics and Prince of Wales Clinical School, University of New South Wales, Sydney.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur.
Arezoo A AssarehCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, University of New South Wales, Sydney, Australia; Neuroscience Research Australia and Primary Dementia Collaborative Research Centre-Assessment and Better Care, University of New South Wales, Sydney.
Nicole A KochanCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, University of New South Wales, Sydney, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick New South Wales, Australia.
Elisabeth WidenInstitute for Molecular Medicine Finland, University of Helsinki, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Finland; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.
Yi-Chen HsiehNeural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Johan G ErikssonFolkhälsan Research Centre, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Vasa Central Hospital, Vasa, Finland.
Christian VoglerPsychiatric University Clinics and Department of Psychology, Division of Molecular Neuroscience, University of Basel, Basel, Switzerland.
John C van SwietenDepartment of Neurology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Joshua M ShulmanDepartments of Neurology and Molecular and Human Genetics, Baylor College of Medicine and The Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas.
Alexa BeiserDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Jerome RotterInstitute for Translational Genomics and Populaton Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Carsten O SchmidtInstitute for Community Medicine, University Medicine Greifswald.
Wolfgang HoffmannGerman Center for Neurodegenerative Diseases, Site Rostock/ Greifswald, Rostock, Germany; Section Epidemiology of Health Care and Community Health, Greifswald.
Markus M NöthenInstitute of Human Genetics, Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn; German Center for Neurodegenerative Diseases, Bonn, Germany.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.
John AttiaCentre for Clinical Epidemiology and Biostatistics, School of Medicine, Newcastle, Australia; Public Health, Faculty of Health, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia; Department of Medicine, John Hunter Hospital, Newcastle, Australia.
Andre G UitterlindenNetherlands Consortium for Healthy Ageing, Leiden, the Netherlands; Department of Internal Medicine, Erasmus Medical Center University Medical Center, Rotterdam, the Netherlands.
Philippe AmouyelInstitut National de la Santé et de la Recherche Médicale Unit 744, Institut Pasteur de Lille, and Université Lille Nord de France, Lille, France; Centre Hospitalier Régional Universitaire de Lille, Lille.
Jean-François DartiguesInstitut National de la Santé et de la Recherche Médicale, Bordeaux University, Talence, France.
Hélène AmievaInstitut National de la Santé et de la Recherche Médicale, Bordeaux University, Talence, France.
Katri RäikkönenInstitute of Behavioural Sciences, University of Helsinki.
Melissa GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland.
Philip A WolfDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Albert HofmanNetherlands Consortium for Healthy Ageing, Leiden, the Netherlands; Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
W T LongstrethDepartments of Neurology, University of Washington; Epidemiology, University of Washington.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington; Epidemiology, University of Washington; Health Services, University of Washington; Group Health Research Institute, Group Health Cooperative, Seattle, Washington.
Eric BoerwinkleBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, Texas.
Philip L DeJagerProgram in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, University of New South Wales, Sydney, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick New South Wales, Australia.
Reinhold SchmidtDivision of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Monique M B BretelerGerman Center for Neurodegenerative Diseases, Site Rostock/ Greifswald, Rostock, Germany; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands; Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Population Health Sciences, University of Bonn, Bonn, Germany; Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts.
Alexander TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Oscar L LopezDepartments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; The Alzheimer׳s Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Sven CichonInstitute of Human Genetics, Universitätsklinikum Bonn, Bonn, Germany; Institute of Neuroscience and Medicine, Research Center Julich, Julich, Germany; Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland.
Daniel I ChasmanHarvard Medical School, Brigham and Women׳s Hospital, Boston, Massachusetts; Division of Preventive Medicine, Brigham and Women׳s Hospital, Boston, Massachusetts.
Francine GrodsteinChanning Division of Network Medicine, Department of Medicine, Brigham and Women׳s Hospital and Harvard Medical School; Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Christophe TzourioInstitut National de la Santé et de la Recherche Médicale, Epidemiology, University of Bordeaux; University Bordeaux Segalen, Bordeaux, France.
Andreas PapassotiropoulosPsychiatric University Clinics and Department of Psychology, Division of Molecular Neuroscience, University of Basel, Basel, Switzerland; Department Biozentrum, Life Sciences Training Facility, Basel, Switzerland.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
M Arfan IkramNetherlands Consortium for Healthy Ageing, Leiden, the Netherlands; Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh; Department of Psychology, The University of Edinburgh.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands; Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands.
Lenore LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland.
Annette L FitzpatrickEpidemiology, University of Washington.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts; Department of Biostatistics, Boston University School of Public Health, Boston; The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.
Thomas H MosleyDepartment of Medicine and Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Boston University · USUniversity of Edinburgh · GBErasmus MC · NLBrigham and Women's Hospital · USNational Institutes of Health · USUniversité de Bordeaux · FRUniversity of Helsinki · FIMRC Human Genetics UnitUNSW Sydney · AUMedical University of Graz · ATUniversitätsmedizin Greifswald · DEUniversity of Alabama at Birmingham · USUniversity of Basel · CHUniversity of Bonn · DEUniversity of Michigan · USUniversity of Mississippi Medical Center · USUniversity of Washington · USIcelandic Heart Association · ISInstitut Pasteur de Lille · FRJohn Hunter Hospital · AU

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, JAMES T. · 1985 to 2019
$43.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI JIN, LEE-WAY · 1991 to 2020
$28.3M
Biotechnology and Biological Sciences Research Council BB/F019394/1Biotechnology and Biological Sciences Research Council S18386Chief Scientist Office CZB/4/505Chief Scientist Office CZB/4/710Chief Scientist Office ETM/55Intramural NIH HHS Z01 AG007270Intramural NIH HHS Z01 AG007380Medical Research Council G0700704Medical Research Council G1001245Medical Research Council MC_PC_U127561128Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR000135NCI NIH HHS 5UO1CA098233NCI NIH HHS CA047988NCI NIH HHS CA134958NCI NIH HHS CA49449NCI NIH HHS CA50385NCI NIH HHS CA55075NCI NIH HHS CA65725NCI NIH HHS CA67262NCI NIH HHS CA87969NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA065725NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA134958NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA098233NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NEI NIH HHS EY015473NEI NIH HHS EY09611NEI NIH HHS R01 EY009611NEI NIH HHS R01 EY015473NHGRI NIH HHS HG004728NHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004728NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL054457NHLBI NIH HHS HL054464NHLBI NIH HHS HL054481NHLBI NIH HHS HL071917NHLBI NIH HHS HL080467NHLBI NIH HHS HL34594NHLBI NIH HHS HL35464NHLBI NIH HHS HL87660NHLBI NIH HHS K99 HL098459NHLBI NIH HHS K99HL098459NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL071917NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01HL120393NHLBI NIH HHS R01HL59367NHLBI NIH HHS R01HL70825NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01HL080295NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIA NIH HHS AG031287NIA NIH HHS AG033193NIA NIH HHS AG08122NIA NIH HHS AG16495NIA NIH HHS K08 AG034290NIA NIH HHS K08AG34290NIA NIH HHS K25 AG041906NIA NIH HHS K25AG41906NIA NIH HHS N01 AG012100NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS P30AG10161NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01AG023629NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG031287NIA NIH HHS R01 AG033193NIA NIH HHS R01AG05133NIA NIH HHS R01AG15819NIA NIH HHS R01AG17917NIA NIH HHS R01AG20098NIA NIH HHS R01AG30146NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG049505NIDDK NIH HHS DK058845NIDDK NIH HHS DK063491NIDDK NIH HHS DK070756NIDDK NIH HHS P01 DK070756NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK058845NIDDK NIH HHS R01 DK084350NINDS NIH HHS NS041558NINDS NIH HHS NS17950NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS041558NINDS NIH HHS U01 NS041588PHS HHS HHSN268200625226CWellcome TrustWellcome Trust WT089062
6 · The paper itself

Abstract

backgroundMemory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting.

methodsWe conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged ≥45 years. Replication of suggestive associations (p < 5 × 10(-6)) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults.

resultsrs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10(-10)) and replication cohorts (p = 5.65 × 10(-8)). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10(-8), and rs6813517 [SPOCK3], p = 2.58 × 10(-8)) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism.

conclusionsThis largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

Indexed as

AgedAged, 80 and overAgingApolipoproteins EClaudin-5Cohort StudiesFemaleGenome-Wide Association StudyGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMemory DisordersMiddle AgedNuclear ProteinsPolymorphism, Single NucleotideApolipoproteins EClaudin-5CLDN5 protein, humanheparitin sulfotransferaseIntracellular Signaling Peptides and ProteinsNuclear ProteinsProteinsProteoglycansSPOCK3 protein, humanSulfotransferasesWDR48 protein, humanAlzheimer diseaseDementiaEpidemiologyGeneticsPopulation-basedVerbal declarative memory

Identifiers

PMID25648963
PMCPMC4513651
OpenAlexW2118010191

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.