ArticleBioMed research international2015
Acute and chronic local inflammatory reaction after implantation of different extracellular porcine dermis collagen matrices in rats.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Trial
- Vancomycin-impregnated decellularized bovine pericardium membranes coating silicone implants: in-vivo biocompatibility and antibacterial efficacy in a rat model.Acta cirurgica brasileira · 2026Article
- Immunogenicity and Integration of a Decellularized Extracellular Matrix-Based Scaffold for the Reconstruction of Human Foreskin: A Preclinical Animal Study.Bioengineering (Basel, Switzerland) · 2025Article
- Decellularized Matrices for the Treatment of Tissue Defects: from Matrix Origin to Immunological Mechanisms.Biomolecules & therapeutics · 2024Review
- Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation.Nature biomedical engineering · 2024Article
- Promoting Angiogenesis Using Immune Cells for Tissue-Engineered Vascular Grafts.Annals of biomedical engineering · 2023Review
- Preparation of laser microporous porcine acellular dermal matrix and observation of wound transplantation.Cell and tissue banking · 2023Article
- Biocompatibility of a New Calcium Silicate-Based Root Canal Sealer Mediated via the Modulation of Macrophage Polarization in a Rat Model.Materials (Basel, Switzerland) · 2022Article
- Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2022Article
- Macrophage Polarization in Response to Biomaterials for Vascularization.Annals of biomedical engineering · 2021Review
- Article
- Polydioxanone-Based Membranes for Bone Regeneration.Polymers · 2021Article
- Investigation of the early healing response to dicationic imidazolium-based ionic liquids: a biocompatible coating for titanium implants.ACS biomaterials science & engineering · 2020Article
- Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Mechanisms underlying heterologous skin scaffold-mediated tissue remodeling.Scientific reports · 2016Article
- Ideal Duration of Pretreatment Using a Gelatin Hydrogel Nonwoven Fabric Prior to Subcutaneous Islet Transplantation.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two cross-linked acellular porcine dermal collagen matrices (Permacol and NRX) were implanted into rats and the acute and chronic local inflammatory tissue reactions were investigated after 7, 14, 28, and 112 days. Both membranes were stable in vivo for up to 112 days. All investigated immune cell populations (CD68+ macrophages, CD163+ macrophages, T lymphocytes, MHC class II positive cells, mast cells, and NK cells) were present. Their amount decreased significantly over time compared to day 7 after implantation. A change from an acute to a chronic inflammation and an associated shift from proinflammatory M1-like to anti-inflammatory M2-like macrophages were observed. In the early phase there was a significant correlation of T cells to CD68+ (M1-like) macrophages, whereas in the chronic phase T lymphocytes were positively correlated with CD163+ (M2-like) macrophages. The material NRX showed an enhanced inflammatory reaction in comparison to Permacol possibly caused by material characteristics such as a twofold higher thickness of the membrane, roughness, and water absorption capacity. Nevertheless, a more pronounced regenerative process as, for example, indicated by nestin expression demonstrated its possible suitability for applications as wound repair material.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.