ArticleBMC plant biology2015
Potential functions of microRNAs in starch metabolism and development revealed by miRNA transcriptome profiling of cassava cultivars and their wild progenitor.
Article in BMC plant biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 59 citations in OpenAlex.
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- MeSPL9 attenuates drought resistance by regulating JA signaling and protectant metabolite contents in cassava.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Identification of miRNAs and Their Targets Involved in Flower and Fruit Development across Domesticated and WildInternational journal of molecular sciences · 2021Article
- MicroRNAs in Woody Plants.Frontiers in plant science · 2021Review
- Genome-Wide Changes of Regulatory Non-Coding RNAs Reveal Pollen Development Initiated at Ecodormancy in Peach.Frontiers in molecular biosciences · 2021Article
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- Systematic Analysis of Alkaline/Neutral Invertase Genes Reveals the Involvement of Smi-miR399 in Regulation ofPlants (Basel, Switzerland) · 2019Article
- Cassava AGPase genes and their encoded proteins are different from those of other plants.Planta · 2019Article
- The miRNA-mRNA Networks Involving Abnormal Energy and Hormone Metabolisms Restrict Tillering in a Wheat MutantInternational journal of molecular sciences · 2019Article
- Integrated transcriptome, small RNA, and degradome analysis reveals the complex network regulating starch biosynthesis in maize.BMC genomics · 2019Article
- Genome-Wide Identification of Putative MicroRNAs in Cassava (BioMed research international · 2019Article
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundMicroRNAs (miRNAs) are small (approximately 21 nucleotide) non-coding RNAs that are key post-transcriptional gene regulators in eukaryotic organisms. More than 100 cassava miRNAs have been identified in a conservation analysis and a repertoire of cassava miRNAs have also been characterised by next-generation sequencing (NGS) in recent studies. Here, using NGS, we profiled small non-coding RNAs and mRNA genes in two cassava cultivars and their wild progenitor to identify and characterise miRNAs that are potentially involved in plant growth and starch biosynthesis.
resultsSix small RNA and six mRNA libraries from leaves and roots of the two cultivars, KU50 and Arg7, and their wild progenitor, W14, were subjected to NGS. Analysis of the sequencing data revealed 29 conserved miRNA families and 33 new miRNA families. Together, these miRNAs potentially targeted a total of 360 putative target genes. Whereas 16 miRNA families were highly expressed in cultivar leaves, another 13 miRNA families were highly expressed in storage roots of cultivars. Co-expression analysis revealed that the expression level of some targets had negative relationship with their corresponding miRNAs in storage roots and leaves; these targets included MYB33, ARF10, GRF1, RD19, APL2, NF-YA3 and SPL2, which are known to be involved in plant development, starch biosynthesis and response to environmental stimuli.
conclusionThe identified miRNAs, target mRNAs and target gene ontology annotation all shed light on the possible functions of miRNAs in Manihot species. The differential expression of miRNAs between cultivars and their wild progenitor, together with our analysis of GO annotation and confirmation of miRNA: target pairs, might provide insight into know the differences between wild progenitor and cultivated cassava.
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