Evidence map›Paper›PMID 25648495›Full record

ArticleJournal of biomechanics2015

Microstructural and mechanical characterization of scarred vocal folds.

Hossein K Heris, Amir K Miri, Nageswara R Ghattamaneni, Nicole Y K Li, Susan L Thibeault, Paul W Wiseman, Luc Mongeau

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. A Review of Hyaluronic Acid and Hyaluronic Acid-based Hydrogels for Vocal Fold Tissue Engineering.Journal of voice : official journal of the Voice Foundation · 2017
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hossein K HerisBiomechanics Laboratory, Department of Mechanical Engineering, McGill University, 817 rue Sherbrooke Ouest, Montreal, QC, Canada H3A 0C3.
Amir K MiriBiomechanics Laboratory, Department of Mechanical Engineering, McGill University, 817 rue Sherbrooke Ouest, Montreal, QC, Canada H3A 0C3. Electronic address: amir.miriramsheh@mail.mcgill.ca.
Nageswara R GhattamaneniPhysics and Chemistry Departments, McGill University, 3600 rue University, Montreal, QC, Canada H3A 2T8.
Nicole Y K LiSchool of Communication Sciences and Disorders, McGill University, 2001 McGill College, Montreal, QC, Canada H3A 1G1.
Susan L ThibeaultDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792, United States.
Paul W WisemanPhysics and Chemistry Departments, McGill University, 3600 rue University, Montreal, QC, Canada H3A 2T8.
Luc MongeauBiomechanics Laboratory, Department of Mechanical Engineering, McGill University, 817 rue Sherbrooke Ouest, Montreal, QC, Canada H3A 0C3.
McGill University · CAUniversity of Wisconsin–Madison · US

Funding

Engineering the Vocal Fold MucosaR01DC004336 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2000 to 2026
$14.6M
Fluid Structure Interactions Within the Human LarynxR01DC005788 · NIDCD · PURDUE UNIVERSITY WEST LAFAYETTE · PI MONGEAU, LUC · 2003 to 2018
$6.4M
Biosimulation of vocal fold surgical injuryR03DC012112 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI LI-JESSEN, NICOLE YEE-KEY · 2012 to 2014
$429k
NIDCD NIH HHS DC004336NIDCD NIH HHS DC005788NIDCD NIH HHS DC012112NIDCD NIH HHS R01 DC004336NIDCD NIH HHS R01 DC005788NIDCD NIH HHS R03 DC012112
6 · The paper itself

Abstract

The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.

Indexed as

Mechanical PhenomenaAnimalsBiomechanical PhenomenaCicatrixCollagenElasticityMaleMicroscopy, Atomic ForceMicroscopy, ConfocalModels, AnimalModels, BiologicalModels, TheoreticalPilot ProjectsRatsRats, Sprague-DawleyVocal CordsCollagenAtomic force microscopyScarringSecond harmonic generationVocal fold

Identifiers

PMID25648495
PMCPMC4337956
OpenAlexW2010590859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.