ArticleThe Journal of veterinary medical science2015
ERK1/2 and AKT are vital factors in regulation of the migration of rat Schwann cells.
Article in The Journal of veterinary medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Paracrine Interaction of Cholangiocellular Carcinoma with Cancer-Associated Fibroblasts and Schwann Cells Impact Cell Migration.Journal of clinical medicine · 2022Article
- Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Article
- TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts.Neural regeneration research · 2019Article
- Protective effect of docosahexaenoic acid on lipotoxicity-mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways.Brain and behavior · 2018Article
- Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro.Scientific reports · 2018Article
- MicroRNA Mediated Regulation of Schwann Cell Migration and Proliferation in Peripheral Nerve Injury.BioMed research international · 2018Review
- Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury.BMC neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After peripheral nerve injury, Wallerian degeneration (WD) occurs in the distal nerve segment. During the process of degeneration, Schwann cells (SCs) dedifferentiate, proliferate and migrate to align in "bands of Büngner", providing structural guidance and growth-promoting substrates to regenerating axons. The molecular signals that trigger SCs migration remain unclear. Here, we explored the molecular characteristics of the migration of cultured SCs prepared from rat sciatic nerves that had degenerated. The results revealed that elevated p-ERK1/2 was coupled with the migration of SCs, activated either by nerve degeneration or the addition of placenta growth factor. However, the inhibition of ERK1/2 activity, which activated the PI3K pathway, did not show a significant negative effect on SC migratory potential. Combined inhibition of ERK1/2 and AKT activity resulted in a significant decrease in SCs motility. These molecular characteristics suggest that both the ERK1/2 and AKT signals are involved in the migratory potential of SCs. It may be helpful to understand the process of nerve regeneration and perspective on promoting peripheral nerve regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.