Evidence map›Paper›PMID 25648409›Full record

ArticleJournal of medical virology2015

Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country.

Carlos E Rodríguez-Martínez, Diego Andrés Rodríguez, Gustavo Nino

Open access · greenAbstract read
In one paragraph

Article in Journal of medical virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Human Adenovirus Associated Hepatic Injury.Frontiers in public health · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Haze is a risk factor contributing to the rapid spread of respiratory syncytial virus in children.Environmental science and pollution research international · 2016
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Carlos E Rodríguez-MartínezDepartment of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Bogota, Colombia; Research Unit, Military Hospital of Colombia, Bogota, Colombia; Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine, Universidad El Bosque, Bogota, Colombia.
Diego Andrés Rodríguez
Gustavo Nino
Fundación Hospital San Pedro · COGeorge Washington University · USUniversidad El Bosque · CO

Funding

Child Health Research Career Development Award (CHRCDA) Program at Children's NationalK12HD001399 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI NATHAN KUPPERMANN · 2001 to 2026
$9.1M
Genetics and Genomic Approaches to Lung Diseases and Disorders in Washington, DCK12HL090020 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI HOFFMAN, ERIC P. · 2007 to 2012
$2.0M
K12 Career Development Program: Omics of Pediatric Lung Diseases in DCK12HL119994 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI FREISHTAT, ROBERT J · 2013 to 2017
$1.3M
NHLBI NIH HHS K12 HL090020NHLBI NIH HHS K12HL090020NHLBI NIH HHS K12 HL119994NICHD NIH HHS K12 HD001399NICHD NIH HHS K12HD001399-13
6 · The paper itself

Abstract

There is growing evidence suggesting greater severity and worse outcomes in children with mixed as compared to single respiratory virus infections. However, studies that assess the risk factors that may predispose a child to a mixture of respiratory syncytial virus (RSV) and adenoviral infections, are scarce. In a retrospective cohort study, the study investigated the epidemiology of RSV and adenovirus infections and predictors of mixed RSV-adenoviral infections in young children hospitalized with acute lower respiratory infection in Bogota, Colombia, South America, over a 2-year period 2009-2011. Of a total of 5,539 children admitted with a diagnosis of acute lower respiratory infection, 2,267 (40.9%) who were positive for RSV and/or adenovirus were selected. Out the total number of cases, 1,416 (62.5%) infections occurred during the 3-month period from March to May, the first rainy season of Bogota, Colombia. After controlling for gender, month when the nasopharyngeal sample was taken, and other pre-existing conditions, it was found that an age greater than 6 months (OR:1.74; CI 95%:1.05-2.89; P = 0.030) and malnutrition as a comorbidity (OR:9.92; CI 95%:1.01-100.9; P = 0.049) were independent predictors of mixed RSV-adenoviral infections in the sample of patients. In conclusion, RSV and adenovirus are significant causes of acute lower respiratory infection in infants and young children in Bogota, Colombia, especially during the first rainy season. The identified predictors of mixed RSV-adenoviral infections should be taken into account when planning intervention, in order to reduce the burden of acute lower respiratory infection in young children living in the country.

Indexed as

AdenoviridaeAdenoviridae InfectionsChild, PreschoolCohort StudiesCoinfectionColombiaDeveloping CountriesFemaleHumansInfantMaleNasopharynxRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsRetrospective Studiesacute respiratory infectionadenovirus infectionsco-infectionpediatricsrespiratory syncytial virus

Identifiers

PMID25648409
PMCPMC5529163
OpenAlexW1948395338

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.