ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015
Duration of Colonization and Determinants of Earlier Clearance of Colonization With Methicillin-Resistant Staphylococcus aureus.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 52 citations in OpenAlex.
- Stopping Hospital Infections With Environmental Services (SHINE): A Cluster-randomized Trial of Intensive Monitoring Methods for Terminal Room Cleaning on Rates of Multidrug-resistant Organisms in the Intensive Care Unit.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
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- Methodologic considerations of household-level methicillin-resistant Staphylococcus aureus decolonization among persons living with HIV.American journal of infection control · 2017Trial
- The Effect of Total Household Decolonization on Clearance of Colonization With Methicillin-Resistant Staphylococcus aureus.Infection control and hospital epidemiology · 2016Trial
- Zoonotic potential of methicillin-resistant Staphylococcus aureus isolated from pets and their owners in Bangladesh.Scientific reports · 2025Article
- Urease promotes pH homeostasis and growth ofJournal of bacteriology · 2025Article
- A prospective cohort study to investigate the transmission and burden ofMicrobial genomics · 2024Article
- Using contact network dynamics to implement efficient interventions against pathogen spread in hospital settings: A modelling study.PLoS medicine · 2024Article
- Risk Factors of Recurrent Infection in Patients with Staphylococcus aureus Bacteremia: a Competing Risk Analysis.Antimicrobial agents and chemotherapy · 2022Article
- Stopping Household Methicillin-resistant Staphylococcusaureus Transmission and Recurrent Infections: An Unmet Challenge.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence.Antibiotics (Basel, Switzerland) · 2021Article
- Environmental Methicillin-resistant Staphylococcus aureus Contamination, Persistent Colonization, and Subsequent Skin and Soft Tissue Infection.JAMA pediatrics · 2020Article
- Impact of Decolonization Protocols and Recurrence in Pediatric MRSA Skin and Soft-Tissue Infections.The Journal of surgical research · 2019Article
- Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.Nature reviews. Microbiology · 2019Review
- Prevention Strategies for Recurrent Community-Associated Staphylococcus aureus Skin and Soft Tissue Infections.Current infectious disease reports · 2019Review
- In-hospital costs of community-acquired colonization with multidrug-resistant organisms at a German teaching hospital.BMC health services research · 2018Article
- Impact of Systemic Antibiotics on Staphylococcus aureus Colonization and Recurrent Skin Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Multidrug and Mupirocin Resistance in Environmental Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates from Homes of People Diagnosed with Community-Onset MRSA Infection.Applied and environmental microbiology · 2017Article
- Factors associated with persistent colonisation with methicillin-resistant Staphylococcus aureus.Epidemiology and infection · 2017Article
- The Impact of Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococcus (VRE) Flags on Hospital Operations.Infection control and hospital epidemiology · 2016Article
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22 authors at 10 institutions in 2 countries.
Funding
Abstract
backgroundThe duration of colonization and factors associated with clearance of methicillin-resistant Staphylococcus aureus (MRSA) after community-onset MRSA skin and soft-tissue infection (SSTI) remain unclear.
methodsWe conducted a prospective cohort study of patients with acute MRSA SSTI presenting to 5 adult and pediatric academic hospitals from 1 January 2010 through 31 December 2012. Index patients and household members performed self-sampling for MRSA colonization every 2 weeks for 6 months. Clearance of colonization was defined as negative MRSA surveillance cultures during 2 consecutive sampling periods. A Cox proportional hazards regression model was developed to identify determinants of clearance of colonization.
resultsTwo hundred forty-three index patients were included. The median duration of MRSA colonization after SSTI diagnosis was 21 days (95% confidence interval [CI], 19-24), and 19.8% never cleared colonization. Treatment of the SSTI with clindamycin was associated with earlier clearance (hazard ratio [HR], 1.72; 95% CI, 1.28-2.30; P < .001). Older age (HR, 0.99; 95% CI, .98-1.00; P = .01) was associated with longer duration of colonization. There was a borderline significant association between increased number of household members colonized with MRSA and later clearance of colonization in the index patient (HR, 0.85; 95% CI, .71-1.01; P = .06).
conclusionsWith a systematic, regular sampling protocol, duration of MRSA colonization was noted to be shorter than previously reported, although 19.8% of patients remained colonized at 6 months. The association between clindamycin and shorter duration of colonization after MRSA SSTI suggests a possible role for the antibiotic selected for treatment of MRSA infection.
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