ArticleEMBO reports2015
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression.
Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism.Nature chemical biology · 2025Article
- Interaction between energy level and starch:fat ratio on intestinal energy metabolism of layer pullets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- A scoping review regarding reproductive capacity modulation based on alpha-ketoglutarate supplementation.Reproduction (Cambridge, England) · 2024Article
- The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity.Antioxidants (Basel, Switzerland) · 2024Review
- FOXO transcription factors as mediators of stress adaptation.Nature reviews. Molecular cell biology · 2024Review
- Investigating the Link between Ketogenic Diet, NAFLD, Mitochondria, and Oxidative Stress: A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart.The Journal of physiology · 2023Article
- A proteomic profile of the healthy human placenta.Clinical proteomics · 2023Review
- FOXOs: masters of the equilibrium.The FEBS journal · 2022Review
- Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations.Cell reports. Medicine · 2021Review
- The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.Nature reviews. Cancer · 2020Review
- Article
- Novel insights into molecular mechanisms of Pseudourostyla cristata encystment using comparative transcriptomics.Scientific reports · 2019Article
- Review
- Mitochondrial function - gatekeeper of intestinal epithelial cell homeostasis.Nature reviews. Gastroenterology & hepatology · 2018Review
- FoxO transcription factors in cancer metabolism.Seminars in cancer biology · 2018Review
- Wild-type and mutated IDH1/2 enzymes and therapy responses.Oncogene · 2018Review
- Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation.Cell reports · 2017Article
- The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma.Journal of Cancer · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FOXO transcription factors are considered bona fide tumor suppressors; however, recent studies showed FOXOs are also required for tumor survival. Here, we identify FOXOs as transcriptional activators of IDH1. FOXOs promote IDH1 expression and thereby maintain the cytosolic levels of α-ketoglutarate and NADPH. In cancer cells carrying mutant IDH1, FOXOs likewise stimulate mutant IDH1 expression and maintain the levels of the oncometabolite 2-hydroxyglutarate, which stimulates cancer cell proliferation and inhibits TET enzymes and histone demethylases. Combined, our data provide a new paradigm for the paradoxical role of FOXOs in both tumor suppression and promotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.