ArticleCancer research and treatment2015
Potential Role of Adjuvant Radiation Therapy in Cervical Thymic Neoplasm Involving Thyroid Gland or Neck.
Article in Cancer research and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Coexistence of intrathyroid thymic carcinoma and papillary thyroid carcinoma: a case report and literature review.Frontiers in oncology · 2024Article
- Case report: Thymoid differentiated carcinoma of thyroid: Two cases.Frontiers in surgery · 2023Article
- Ectopic Cervical Thymoma: An Uncommon Entity.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Article
- Thyroid Carcinoma Showing Thymus-like Differentiation (CASTLE): A Case Report.Life (Basel, Switzerland) · 2022Article
- Genomic variation associated with carcinoma showing thymus-like elements (CASTLE) in thyroid gland.Laryngoscope investigative otolaryngology · 2022Article
- Overview of the 2022 WHO Classification of Thyroid Neoplasms.Endocrine pathology · 2022Review
- Recurrence of carcinoma showing thymus-like differentiation (CASTLE) involving the thyroid gland.Thyroid research · 2021Article
- [Ectopic cervical thymoma misdiagnosed as thyroid nodule：a case report].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Thyroid Carcinoma Showing Thymus-Like Differentiation (CASTLE) with Tracheal Invasion: A Case Report.The American journal of case reports · 2019Review
- The 'CASTLE' tumour: An extremely rare presentation of a thyroid malignancy. A case report.Annals of medicine and surgery (2012) · 2019Article
- [Ectopic thymic tissue and ectopic thymic tumors].Der Pathologe · 2018Review
- CASTLE Thyroid Tumor: A Case Report and Literature Review.Frontiers in oncology · 2017Article
- Clinical outcome of intensity modulated radiotherapy for carcinoma showing thymus-like differentiation.Oncotarget · 2016Article
- The spectrum of ectopic thymomas.Virchows Archiv : an international journal of pathology · 2016Review
- Thyroid Carcinoma Showing Thymic-Like Differentiation Causing Fracture of the Trachea.Case reports in medicine · 2016Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study is to assess the clinicopathologic features, treatment outcomes, and role of adjuvant radiation therapy (RT) in cervical thymic neoplasm involving the thyroid gland or neck. MATERIALS AND
methodsThe medical and pathologic records of eight patients with cervical thymic neoplasm were reviewed retrospectively. All patients underwent surgical resection, including thyroidectomy or mass excision. Adjuvant RT was added in five patients with adverse clinicopathologic features. The radiation doses ranged from 54 Gy/27 fractions to 66 Gy/30 fractions delivered to the primary tumor bed and pathologically involved regional lymphatics using a 3-dimensional conformal technique.
resultsEight cases of cervical thymic neoplasm included three patients with carcinoma showing thymus-like differentiation (CASTLE) and five with ectopic cervical thymoma. The histologic subtypes of ectopic cervical thymoma patients were World Health Organization (WHO) type B3 thymoma in one, WHO type B1 thymoma in two, WHO type AB thymoma in one, and metaplastic thymoma in one, respectively. The median age was 57 years (range, 40 to 76 years). Five patients received adjuvant RT: three with CASTLE; one with WHO type B3; and one with WHO type AB with local invasiveness. After a median follow-up period of 49 months (range, 11 to 203 months), no recurrence had been observed, regardless of adjuvant RT.
conclusionAdjuvant RT after surgical resection might be worthwhile in patients with CASTLE and ectopic cervical thymoma with WHO type B2-C and/or extraparenchymal extension, as similarly indicated for primary thymic epithelial tumors. A longer follow-up period may be needed in order to validate this strategy.
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