ArticleCognition & emotion2016
Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype.
Article in Cognition & emotion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk.International journal of molecular sciences · 2019Pooled it
- The effects of rumination on internalising symptoms in the context of the COVID-19 pandemic among mothers and their offspring: a brief report.Cognition & emotion · 2022Article
- Rumination and Emotional Profile in Children with Specific Learning Disorders and Their Parents.International journal of environmental research and public health · 2020Article
- Functional connectivity of reflective and brooding rumination in depressed and healthy women.Cognitive, affective & behavioral neuroscience · 2018Article
- Corticotropin-releasing factor 1 receptor haplotype and cognitive features of major depression.Translational psychiatry · 2018Review
- Partial replication of two rumination-related candidate gene studies.Cognition & emotion · 2017Article
- Gender Moderation of the Intergenerational Transmission and Stability of Depressive Symptoms from Early Adolescence to Early Adulthood.Journal of youth and adolescence · 2017Article
- Integrating NIMH Research Domain Criteria (RDoC) into Depression Research.Current opinion in psychology · 2015Article
- Pupillary reactivity to sad stimuli as a biomarker of depression risk: Evidence from a prospective study of children.Journal of abnormal psychology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
There is growing evidence that brooding rumination plays a key role in the intergenerational transmission of major depressive disorder (MDD) and may be an endophenotype for depression risk. However, less is known about the mechanisms underlying this role. Therefore, the goal of the current study was to examine levels of brooding in children of mothers with a history of MDD (n = 129) compared to children of never depressed mothers (n = 126) and to determine whether the variation in a gene known to influence hypothalamic-pituitary-adrenal axis functioning--corticotropin-releasing hormone receptor 1 (CRHR1)--would moderate the link between maternal MDD and children's levels of brooding. We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than children of mothers with no lifetime depression history but that this link would be stronger among children carrying no copies of the protective CRHR1 TAT haplotype. Our results supported these hypotheses and suggest that the development of brooding among children of depressed mothers, particularly children without the protective CRHR1 haplotype, may serve as an important mechanism of risk for the intergenerational transmission of depression.
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Registered trials
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