Evidence map›Paper›PMID 25647685›Full record

Trial reportPloS one2015

Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study.

David Bann, Don Hire, Todd Manini, Rachel Cooper, Anda Botoseneanu, Mary M McDermott, Marco Pahor, Nancy W Glynn, Roger Fielding, Abby C King and 5 more

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 4 countries.

David BannMRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Don HireDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Todd ManiniDepartment of Aging & Geriatric Research, University of Florida, Gainesville, Florida, United States of America.
Rachel CooperMRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.
Anda BotoseneanuDepartment of Health Policy Studies and Institute of Gerontology, University of Michigan-Dearborn/Ann Arbor, Ann Arbor, Michigan, United States of America.
Mary M McDermottNorthwestern University, Feinberg School of Medicine, Chicago, United States of America.
Marco PahorDepartment of Aging & Geriatric Research, University of Florida, Gainesville, Florida, United States of America.
Nancy W GlynnDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, United States of America.
Roger FieldingNutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, United States of America.
Abby C KingStanford University School of Medicine, Stanford, CA, United States of America.
Timothy ChurchPennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Walter T AmbrosiusDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Thomas M Gill
Thomas GillYale School of Medicine, New Haven, Connecticut, United States of America.
LIFE Study Group
University of Florida · USWake Forest University · USGeneral Department of Preventive Medicine · VNPennington Biomedical Research Center · USStanford University · USTufts University · USUCL Australia · AUUniversity College London · GBUniversity of Pittsburgh · USYale University · US

Funding

UF FIELD CENTERU01AG022376 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PAHOR, MARCO · 2003 to 2015
$83.3M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
Improving Outcome Measurement for Medical Rehabilitaiton Clinical TrialsR24HD065688 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JETTE, ALAN MAURICE, ZAFONTE, ROSS DENNIS · 2010 to 2014
$3.9M
Intramural NIH HHSMedical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/4NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001085NCRR NIH HHS UL1 RR025744NIA NIH HHS 1P30 AG028740NIA NIH HHS 1P30AG031679NIA NIH HHS 1 P30 AG21332NIA NIH HHS 3U01AG022376-05A2SNIA NIH HHS K07AG3587NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG021342NIA NIH HHS P30AG021342NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG031679NIA NIH HHS U01 AG022376NIA NIH HHS U01AG22376NICHD NIH HHS 1R24HD065688-01A1NICHD NIH HHS R24 HD065688
6 · The paper itself

Abstract

backgroundIdentifying modifiable determinants of fat mass and muscle strength in older adults is important given their impact on physical functioning and health. Light intensity physical activity and sedentary behavior are potential determinants, but their relations to these outcomes are poorly understood. We evaluated associations of light intensity physical activity and sedentary time-assessed both objectively and by self-report-with body mass index (BMI) and grip strength in a large sample of older adults.

methodsWe used cross-sectional baseline data from 1130 participants of the Lifestyle Interventions and Independence for Elders (LIFE) study, a community-dwelling sample of relatively sedentary older adults (70-89 years) at heightened risk of mobility disability. Time spent sedentary and in light intensity activity were assessed using an accelerometer worn for 3-7 days (Actigraph GT3X) and by self-report. Associations between these exposures and measured BMI and grip strength were evaluated using linear regression.

resultsGreater time spent in light intensity activity and lower sedentary times were both associated with lower BMI. This was evident using objective measures of lower-light intensity, and both objective and self-reported measures of higher-light intensity activity. Time spent watching television was positively associated with BMI, while reading and computer use were not. Greater time spent in higher but not lower intensities of light activity (assessed objectively) was associated with greater grip strength in men but not women, while neither objectively assessed nor self-reported sedentary time was associated with grip strength.

conclusionsIn this cross-sectional study, greater time spent in light intensity activity and lower sedentary times were associated with lower BMI. These results are consistent with the hypothesis that replacing sedentary activities with light intensity activities could lead to lower BMI levels and obesity prevalence among the population of older adults. However, longitudinal and experimental studies are needed to strengthen causal inferences.

Indexed as

Body Mass IndexHand StrengthMotor ActivitySedentary BehaviorAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleSelf Report

Identifiers

PMID25647685
PMCPMC4315494
OpenAlexW2142443169

What OpenQuestion holds

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LicenceCC0
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.