ArticleInternational archives of occupational and environmental health2015
DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.
Article in International archives of occupational and environmental health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N'-(3,5-Difluorobenzylidene)Pyridine-4-Carbohydrazide.Journal of applied toxicology : JAT · 2026Article
- Towards a validation of the standard and enzyme-linked comet assay: a retrospective variability analysis.Archives of toxicology · 2026Review
- Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay.International archives of occupational and environmental health · 2024Article
- Land use as an effective factor on the occurrence of chromosomal diseases in Brazil.International journal of molecular epidemiology and genetics · 2021Article
- Herbicide biomonitoring in agricultural workers in Valle del Mayo, Sonora Mexico.Environmental science and pollution research international · 2020Article
- Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effect of one pesticide spraying season on DNA damage was measured on B and T lymphocytes among open-field farmers and controls.
methodsAt least two peripheral blood samples were collected from each individual: one in a period without any pesticide application, several weeks after the last use (January, at period P0), and another in the intensive pesticide spraying period (May or June, at period P4). DNA damage was studied by alkaline comet assay on isolated B or T lymphocytes.
resultsLongitudinal comparison of DNA damage observed at both P0 and P4 periods revealed a statistically significant genotoxic effect of the pesticide spraying season in both B (P = 0.02) and T lymphocytes (P = 0.02) in exposed farmers. In contrast, non-farmers did not show any significant modifications. DNA damage levels in B and T lymphocytes were significantly higher in farmers than in non-farmers during the P4 period (P = 0.003 and P = 0.001 for B and T lymphocytes, respectively) but not during the P0 period. The seasonal effect observed among farmers was not correlated with either total farm area, farm area devoted to crops or recent solar exposure. On average, farmers used pesticides for 21 days between P0 and P4. Between the two time points studied, there was a tendency for a potential effect of the number of days of fungicide treatments (r (2) = 0.43; P = 0.11) on T lymphocyte DNA damage.
conclusionsA genotoxic effect was found in lymphocytes of farmers exposed to pesticides, suggesting in particular the possible implication of fungicides.
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