SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2015
Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Association between HDL-C levels and menopause: a meta-analysis.Hormones (Athens, Greece) · 2021Pooled it
- Dysphagia Risk and Its Association with Nutritional Status in Multiple Sclerosis: A Preliminary Study.Nutrients · 2026Article
- Article
- Enabling equitable and inclusive travel experiences for dysphagia patients: a call to action for the aviation industry.Frontiers in rehabilitation sciences · 2026Article
- The Comparison of Quality of Life in Patients with Mild-Moderate Severity of Multiple Sclerosis with and without Dysphagia.Dysphagia · 2025Article
- Infection, Relapses, and Pseudo-Relapses in Individuals With Multiple Sclerosis.Neurology. Clinical practice · 2025Article
- The Validation of the Italian Version of the Munich Swallowing Score (IT-MUCSS) Against the Fiberoptic Endoscopic Evaluation of Swallowing and Food Intake Modalities in Patients with Neurogenic Dysphagia: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Article
- Understanding Dysphagia Care in Pakistan: A Survey of Current Speech Language Therapy Practice.Dysphagia · 2024Article
- Risk factors and long-term outcomes of oropharyngeal dysphagia in persons with multiple sclerosis: a systematic review protocol.Systematic reviews · 2024Article
- CHARACTERISTICS OF SPEECH AND SWALLOWING IN PERSONS WITH MULTIPLE SCLEROSIS.Acta clinica Croatica · 2024Review
- DYMUS-Hr self-assessment questionnaire (Croatian version) for dysphagia in multiple sclerosis-validity, reliability, and cross-cultural adaptation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Validation of the Czech Version of the Dysphagia in Multiple Sclerosis Questionnaire (DYMUS).Dysphagia · 2023Article
- Non-Contact Assessment of Swallowing Dysfunction Using Smartphone Captured Skin Displacements.Sensors (Basel, Switzerland) · 2023Article
- Costs of post-stroke dysphagia during acute hospitalization from a health-insurance perspective.European stroke journal · 2023Article
- Autoimmune Neurogenic Dysphagia.Dysphagia · 2022Review
- Article
- Bulbar Symptoms as an Unusual Presentation of Multiple Sclerosis: A Case Report.European journal of case reports in internal medicine · 2022Article
- Depression, Anxiety, and Stress Relative to Swallowing Impairment in Persons with Multiple Sclerosis.Dysphagia · 2021Article
- Diagnosis and treatment of neurogenic dysphagia - S1 guideline of the German Society of Neurology.Neurological research and practice · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although dysphagia was recognized as a clinical finding in multiple sclerosis (MS) as early as 1877, it has not received enough attention yet. With the progress of diagnostic method for dysphagia, there has been a rapid development in estimating the prevalence of deglutition disorder in MS. In this review, we aimed to conduct a systematic review and meta-analysis of published literature to establish the prevalence of dysphagia in multiple sclerosis. We systematically searched Embase, PubMed databases and Cochrane library from 1980 to August 2014, supplemented by hand searching to identify relevant studies. We used random-effects model to calculate pooled prevalence. Potential sources of heterogeneity were explored using sensitivity test and subgroup analysis, meta-regression analysis. Of 198 retrieved articles, 15 eligible surveys with a total population of 4,510 met the criteria. Twelve studies provided an estimate based on subjective screening test, which proved substantial heterogeneity (Cochran's χ(2) significant at p < 0.0001; I(2) = 92.4 %, 95 % CI 31-42 %), with a combined prevalence estimate of 36 %. Four studies provided an estimate based on objective measurements (clinical or instrument tools), which were substantial heterogeneity (Cochran's χ(2) significant at p < 0.005; I(2) = 77 %, 95 % CI 67-94 %), with a pooled prevalence estimate of 81 %. A large heterogeneity still existed after conducting several subgroup analyses and sensitivity tests. The findings confirm that more than one-third of the multiple sclerosis patients are suffering from swallowing difficulties. Therefore, we should be careful to interpret the pooled estimate due to the substantial heterogeneity between studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.