ArticleThyroid : official journal of the American Thyroid Association2015
Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.
Article in Thyroid : official journal of the American Thyroid Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- PathExpSurv: pathway expansion for explainable survival analysis and disease gene discovery.BMC bioinformatics · 2023Article
- A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencing.Frontiers in cell and developmental biology · 2023Article
- Diagnostic and prognostic value of Stanniocalcin 1 expression in papillary thyroid cancer.Endocrine · 2022Article
- GeneChip expression profiling identifiedAnnals of translational medicine · 2022Article
- Stanniocalcin 1 is a prognostic biomarker in glioma.Oncology letters · 2020Article
- Expression, function and clinical application of stanniocalcin-1 in cancer.Journal of cellular and molecular medicine · 2020Review
- The stress-activated protein kinase pathway and the expression of stanniocalcin-1 are regulated by miR-146b-5p in papillary thyroid carcinogenesis.Cancer biology & therapy · 2020Article
- Functions of stem cells of thyroid glands in health and disease.Reviews in endocrine & metabolic disorders · 2019Review
- STC1 promotes cell apoptosis via NF-κB phospho-P65 Ser536 in cervical cancer cells.Oncotarget · 2017Article
- An Adult Mouse Thyroid Side Population Cell Line that Exhibits Enriched Epithelial-Mesenchymal Transition.Thyroid : official journal of the American Thyroid Association · 2017Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundMouse thyroid side population (SP) cells consist of a minor population of mouse thyroid cells that may have multipotent thyroid stem cell characteristics. However the nature of thyroid SP cells remains elusive, particularly in relation to thyroid cancer. Stanniocalcin (STC) 1 and 2 are secreted glycoproteins known to regulate serum calcium and phosphate homeostasis. In recent years, the relationship of STC1/2 expression to cancer has been described in various tissues.
methodMicroarray analysis was carried out to determine genes up- and down-regulated in thyroid SP cells as compared with non-SP cells. Among genes up-regulated, stanniocalcin 1 (STC1) was chosen for study because of its expression in various thyroid cells by Western blotting and immunohistochemistry.
resultsGene expression analysis revealed that genes known to be highly expressed in cancer cells and/or involved in cancer invasion/metastasis were markedly up-regulated in SP cells from both intact as well as partial thyroidectomized thyroids. Among these genes, expression of STC1 was found in five human thyroid carcinoma-derived cell lines as revealed by analysis of mRNA and protein, and its expression was inversely correlated with the differentiation status of the cells. Immunohistochemical analysis demonstrated higher expression of STC1 in the thyroid tumor cell line and thyroid tumor tissues from humans and mice.
conclusionThese results suggest that SP cells contain a population of cells that express genes also highly expressed in cancer cells including Stc1, which warrants further study on the role of SP cells and/or STC1 expression in thyroid cancer.
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