ArticlePloS one2015
Prostatic inflammation induces urinary frequency in adult mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Metabolic syndrome, inflammation and lower urinary tract symptoms: possible translational links.Prostate cancer and prostatic diseases · 2016Pooled it
- Spoti-find: a novel, open-source void spot assay image analysis tool.American journal of physiology. Renal physiology · 2026Article
- Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice.Current research in toxicology · 2025Article
- The impact of short term, long term and intermittentAmerican journal of clinical and experimental urology · 2023Article
- E-cadherin deficiency promotes prostate macrophage inflammation and bladder overactivity in aged male mice.Aging · 2022Article
- Male Lower Urinary Tract Dysfunction: An Underrepresented Endpoint in Toxicology Research.Toxics · 2022Review
- Article
- Osteopontin Deficiency Ameliorates Prostatic Fibrosis and Inflammation.International journal of molecular sciences · 2021Article
- Prostate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.Endocrinology · 2021Article
- Claudin-1 down-regulation in the prostate is associated with aging and increased infiltration of inflammatory cells in BPH.American journal of clinical and experimental urology · 2021Article
- A uropathogenicAmerican journal of physiology. Renal physiology · 2021Article
- Novel catheter design enables transurethral catheterization of male mice.American journal of physiology. Renal physiology · 2020Article
- Urethral dysfunction in a rat model of chemically induced prostatic inflammation: potential involvement of the MRP5 pump.American journal of physiology. Renal physiology · 2020Article
- Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.American journal of physiology. Renal physiology · 2019Article
- Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis.Scientific reports · 2019Article
- Urinary Metabolomic and Proteomic Analyses in a Mouse Model of Prostatic Inflammation.Urine (Amsterdam, Netherlands) · 2019Article
- Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection.JCI insight · 2019Article
- Bladder overactivity and afferent hyperexcitability induced by prostate-to-bladder cross-sensitization in rats with prostatic inflammation.The Journal of physiology · 2019Article
- Comprehensive urinary metabolomic characterization of a genetically induced mouse model of prostatic inflammation.International journal of mass spectrometry · 2018Article
- Void spot assay procedural optimization and software for rapid and objective quantification of rodent voiding function, including overlapping urine spots.American journal of physiology. Renal physiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Lower urinary tract symptoms (LUTS) including urinary frequency and nocturia are common in aging men. Recent studies have revealed a strong association of prostatic inflammation with LUTS. We developed an animal model of bacterial induced, isolated prostatic inflammation and examined the effect of prostatic inflammation on voiding behavior in adult C57BL/6J mice. Prostatic inflammation was induced by transurethral inoculation of uropathogenic E. coli-1677. Bacterial cystitis was prevented by continuous administration of nitrofurantoin. Hematoxylin and eosin (H&E) staining and bacterial culture were preformed to validate our animal model. Voiding behavior was examined by metabolic cage testing on post-instillation day 1 (PID 1), PID 4, PID 7 and PID 14 and both voiding frequency and volume per void were determined. Mice with prostatic inflammation showed significantly increased voiding frequency at PID 1, 7 and 14, and decreased volume per void at all time points, as compared to mice instilled with saline and receiving nitrofurantoin (NTF). Linked analysis of voiding frequency and voided volumes revealed an overwhelming preponderance of high frequency, low volume voiding in mice with prostatic inflammation. These observations suggest that prostatic inflammation may be causal for symptoms of urinary frequency and nocturia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.