Evidence map›Paper›PMID 25646893›Full record

ReviewJournal of assisted reproduction and genetics2015

Contemporary evidence on the physiological role of reactive oxygen species in human sperm function.

Stefan S Du Plessis, Ashok Agarwal, Jacques Halabi, Eva Tvrda

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02839447 (A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0), which is not on this map. Cited by 132 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 7 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02839447 withdrawnnot on this mapstarted 2025, after this paper: background citation

A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0

TypeobservationalSponsorAytu BioPharma, Inc.Ran2025 to 2026Enrolled0ConditionsMale InfertilityArmsDiagnostic
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 7 syntheses or guidelines pooled it, 271 citations in OpenAlex.

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  6. Antioxidants for male subfertility.The Cochrane database of systematic reviews · 2022
    Pooled it
  7. Association between exposure to ambient air pollution and semen quality in adults: a meta-analysis.Environmental science and pollution research international · 2022
    Pooled it
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Stefan S Du PlessisCenter for Reproductive Medicine, Cleveland Clinic, 10681 Carnegie Avenue, Mail Code X-11, Cleveland, OH, 44195, USA, ssdp@sun.ac.za.
Ashok Agarwal
Jacques Halabi
Eva Tvrda
Cleveland Clinic · USSlovak University of Agriculture · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) play an important role in male fertility. Overproduction of reactive oxygen species (ROS) has been associated with a variety of male fertility complications, including leukocytospermia, varicocele and idiopathic infertility. The subsequent oxidative insult to spermatozoa can manifest as insufficient energy metabolism, lipid peroxidation and DNA damage, leading to loss of motility and viability. However, various studies have demonstrated that physiological amounts of ROS play important roles in the processes of spermatozoa maturation, capacitation, hyperactivation and acrosome reaction. It is therefore crucial to define and understand the delicate oxidative balance in male reproductive cells and tissues for a better understanding of both positive as well as negative impact of ROS production on the fertilizing ability. This review will discuss the specific physiological roles, mechanisms of action and effects that ROS have on the acquisition of structural integrity and physiological activity of spermatozoa.

Indexed as

HumansInfertility, MaleMaleOxidative StressReactive Oxygen SpeciesSpermatozoaReactive Oxygen Species

Identifiers

PMID25646893
PMCPMC4380893
OpenAlexW2022443708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.