Evidence map›Paper›PMID 25646592›Full record

ArticleTranslational psychiatry2015

Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats.

R K Quinn, A L Brown, B J Goldie, E M Levi, P W Dickson, D W Smith, M J Cairns, C V Dayas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Noncoding RNA therapeutics for substance use disorder.Advances in drug and alcohol research · 2022
    Article
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  20. Decreased Expression of Plasma MicroRNA in Patients with Methamphetamine (MA) Use Disorder.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

R K Quinn1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
A L Brown1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
B J Goldie1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
E M Levi1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
P W Dickson1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
D W Smith1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
M J Cairns1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
C V Dayas1] Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia [2] The Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW, Australia [3] Hunter Medical Research Institute, Newcastle, NSW, Australia.
University of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, we published data using an animal model that allowed us to characterize animals into two groups, addiction vulnerable and addiction resilient, where we identified that addiction/relapse vulnerability was associated with deficits in synaptic plasticity-associated gene expression in the dorsal striatum (DS). Notable was the strong reduction in expression for activity-regulated cytoskeleton-associated protein (Arc) considered a master regulator of synaptic plasticity. In the present study, we confirmed that Arc messenger RNA was significantly decreased in the DS, but importantly, we identified that this reduction was restricted to the dorsomedial (DMS) and not dorsolateral striatum (DLS). There is recent evidence of microRNA (miRNA)-associated posttranscriptional suppression of Arc and animal models of addiction have identified a key role for miRNA in the regulation of addiction-relevant genes. In further support of this link, we identified several differentially expressed miRNA with the potential to influence addiction-relevant plasticity genes, including Arc. A key study recently reported that miR-212 expression is protective against compulsive cocaine-seeking. Supporting this hypothesis, we found that miR-212 expression was significantly reduced in the DMS but not DLS of addiction-vulnerable animals. Together, our data provide strong evidence that miRNA promote ongoing plasticity deficits in the DS of addiction-vulnerable animals.

Indexed as

Behavior, AnimalAnimalsCocaine-Related DisordersCorpus StriatumCytoskeletal ProteinsDisease Models, AnimalDrug-Seeking BehaviorGene Expression ProfilingMicroRNAsNeostriatumNerve Tissue ProteinsNeuronal PlasticityRatsRNA, Messengeractivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsMicroRNAsMIRN212 microRNA, ratNerve Tissue ProteinsRNA, Messenger

Identifiers

PMID25646592
PMCPMC4445746
OpenAlexW2050168065

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.