Evidence map›Paper›PMID 25646527›Full record

ArticleStem cells translational medicine2015

Pre-exposure of human adipose mesenchymal stem cells to soluble factors enhances their homing to brain cancer.

Chris L Smith, Kaisorn L Chaichana, Young M Lee, Benjamin Lin, Kevin M Stanko, Thomas O'Donnell, Saksham Gupta, Sagar R Shah, Joanne Wang, Olindi Wijesekera and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Stem cell therapy for hepatocellular carcinoma and end-stage liver disease.Journal of the Egyptian National Cancer Institute · 2023
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Time-Dependent Internalization of S100B by Mesenchymal Stem CellsFrontiers in cell and developmental biology · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Nanoparticles for Stem Cell Therapy Bioengineering in Glioma.Frontiers in bioengineering and biotechnology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chris L SmithDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kaisorn L ChaichanaDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Young M LeeDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Benjamin LinDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kevin M StankoDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Thomas O'DonnellDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Saksham GuptaDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sagar R ShahDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Joanne WangDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Olindi WijesekeraDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Michael DelannoyDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Andre LevchenkoDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA aquinon2@jhmi.edu andre.levchenko@yale.edu.
Alfredo Quiñones-HinojosaDepartments of Neurosurgery and Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA aquinon2@jhmi.edu andre.levchenko@yale.edu.

Funding

Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationR01NS070024 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2010 to 2014
$2.4M
BMP4 Engineered Mesenchymal Stem Cell Therapy for GlioblastomaR01CA183827 · NCI · MAYO CLINIC JACKSONVILLE · PI QUINONES-HINOJOSA, ALFREDO · 2015 to 2019
$1.9M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA183827NINDS NIH HHS R01 NS070024
6 · The paper itself

Abstract

Recent research advances have established mesenchymal stem cells (MSCs) as a promising vehicle for therapeutic delivery. Their intrinsic tropism for brain injury and brain tumors, their lack of immunogenicity, and their ability to breach the blood-brain barrier make these cells an attractive potential treatment of brain disorders, including brain cancer. Despite these advantages, the efficiency of MSC homing to the brain has been limited in commonly used protocols, hindering the feasibility of such therapies. In the present study, we report a reproducible, comprehensive, cell culture-based approach to enhance human adipose-derived MSC (hAMSC) engraftment to brain tumors. We used micro- and nanotechnological tools to systematically model several steps in the putative homing process. By pre-exposing hAMSCs to glioma-conditioned media and the extracellular matrix proteins fibronectin and laminin, we achieved significant enhancements of the individual homing steps in vitro. This homing was confirmed in an in vivo rodent model of brain cancer. This comprehensive, cell-conditioning approach provides a novel method to enhance stem cell homing to gliomas and, potentially, other neurological disorders.

Indexed as

Mesenchymal Stem Cell TransplantationAdipocytesAnimalsBrain NeoplasmsCell Line, TumorCulture Media, ConditionedGliomaHeterograftsHumansMesenchymal Stem CellsMice, SCIDNeoplasms, ExperimentalCulture Media, ConditionedAdiposeBone marrowBrain tumorGlioblastomaHomingMesenchymal stem cells

Identifiers

PMID25646527
PMCPMC4339851

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.