ArticleProceedings of the National Academy of Sciences of the United States of America2015
Copper economy in Chlamydomonas: prioritized allocation and reallocation of copper to respiration vs. photosynthesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 92 citations in OpenAlex.
- Estimation of chloroplast macromolecular complex copy numbers and subunit stoichiometries during the Chlamydomonas reinhardtii cell cycle.The Plant journal : for cell and molecular biology · 2026Article
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- The Elements of Life, Photosynthesis and Genomics.Journal of molecular biology · 2025Review
- A defined growth medium for trace metal limitation studies inbioRxiv : the preprint server for biology · 2025Article
- Identification of a gene controlling levels of the copper response regulator 1 transcription factor in Chlamydomonas reinhardtii.The Plant cell · 2024Article
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- APX2 Is an Ascorbate Peroxidase-Related Protein that Regulates the Levels of Plastocyanin in Chlamydomonas.Plant & cell physiology · 2024Article
- Distinct function of Chlamydomonas CTRA-CTR transporters in Cu assimilation and intracellular mobilization.Metallomics : integrated biometal science · 2024Article
- Ascorbate Peroxidase 2 (APX2) of Chlamydomonas Binds Copper and Modulates the Copper Insertion into Plastocyanin.Antioxidants (Basel, Switzerland) · 2023Article
- Chlamydomonas reinhardtii: a model for photosynthesis and so much more.Nature methods · 2023Article
- Zn deficiency disrupts Cu and S homeostasis in Chlamydomonas resulting in over accumulation of Cu and Cysteine.Metallomics : integrated biometal science · 2023Article
- Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7.The Plant cell · 2022Article
- Copper Requirement and Acquisition by Marine Microalgae.Microorganisms · 2022Review
- Review
- Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance.PLoS pathogens · 2022Article
- Chlamydomonas ATX1 is essential for Cu distribution to multiple cupro-enzymes and maintenance of biomass in conditions demanding cupro-enzyme-dependent metabolic pathways.Plant direct · 2022Article
- Copper Metabolism inFrontiers in cell and developmental biology · 2022Article
- Age Dependent Partitioning Patterns of Essential Nutrients Induced by Copper Feeding Status in Leaves and Stems of Poplar.Frontiers in plant science · 2022Article
- Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms.Journal of experimental botany · 2021Article
- Phenotypic changes in microalgae at acidic pH mediate their tolerance to higher concentrations of transition metals.Current research in microbial sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Inorganic elements, although required only in trace amounts, permit life and primary productivity because of their functions in catalysis. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce this quota. A well-studied copper-sparing mechanism that operates in microalgae faced with copper deficiency is the replacement of the abundant copper protein plastocyanin with a heme-containing substitute, cytochrome (Cyt) c6. This switch, which is dependent on a copper-sensing transcription factor, copper response regulator 1 (CRR1), dramatically reduces the copper quota. We show here that in a situation of marginal copper availability, copper is preferentially allocated from plastocyanin, whose function is dispensable, to other more critical copper-dependent enzymes like Cyt oxidase and a ferroxidase. In the absence of an extracellular source, copper allocation to Cyt oxidase includes CRR1-dependent proteolysis of plastocyanin and quantitative recycling of the copper cofactor from plastocyanin to Cyt oxidase. Transcriptome profiling identifies a gene encoding a Zn-metalloprotease, as a candidate effecting copper recycling. One reason for the retention of genes encoding both plastocyanin and Cyt c6 in algal and cyanobacterial genomes might be because plastocyanin provides a competitive advantage in copper-depleted environments as a ready source of copper.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.