ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Article
- Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice.bioRxiv : the preprint server for biology · 2023Article
- Cannabis Use and Neuroadaptation: A Call for ΔFrontiers in psychiatry · 2022Article
- Intrinsic differences in insular circuits moderate the negative association between nicotine dependence and cingulate-striatal connectivity strength.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit/Hyperactivity Disorder.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Altered neural connectivity in adult female rats exposed to early life social stress.Behavioural brain research · 2017Article
- The power of using functional fMRI on small rodents to study brain pharmacology and disease.Frontiers in pharmacology · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionIt is unknown how the timing between doses might affect nicotine's impact on neural activity. Our objective was to examine how the interdose interval affects nicotine's impact on resting-state functional connectivity (rsFC). MATERIALS AND
methodsAdult male Sprague-Dawley rats were administered nicotine daily (0.4 mg/kg) over 6 days while control animals received saline vehicle. Functional magnetic resonance imaging was used to measure rsFC before and after a challenge dose of nicotine (0.4 mg/kg) delivered for the first time and 3, 6, 12, or 24hr after the previous dose.
resultsAs the interval between nicotine doses increased from 3 to 24hr, the strength of rsFC increased in some circuits, particularly the nucleus accumbens and prefrontal circuits, and decreased in others, namely the interpeduncular nucleus, hippocampus, caudoputamen, retrosplenial cortex, ventral tegmental, and the insular circuits.
conclusionsThese data indicate that the effect that nicotine has on the brain is affected by the amount of time that has passed since the previous dose. The effect on rsFC of cumulative doses is not additive. This may have important implications for the study of nicotine addiction as it implies that the same dose of nicotine might have a different impact on the brain depending on the time elapsed from the previous exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.