Evidence map›Paper›PMID 25646338›Full record

SynthesisThe American journal of clinical nutrition2015

Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Dariush Mozaffarian, Edmond K Kabagambe, Catherine O Johnson, Rozenn N Lemaitre, Ani Manichaikul, Qi Sun, Millennia Foy, Lu Wang, Howard Wiener, Marguerite R Irvin and 19 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Use of Mendelian Randomization to Unveil Metabolic Markers inJournal of Korean medical science · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 1 institution in 1 country.

Dariush MozaffarianFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Edmond K KabagambeFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Catherine O JohnsonFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Rozenn N LemaitreFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Ani ManichaikulFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Qi SunFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Millennia FoyFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Lu WangFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Howard WienerFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Marguerite R IrvinFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Stephen S RichFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Hongyu WuFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Majken K JensenFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Daniel I ChasmanFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Audrey Y ChuFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Myriam FornageFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Lyn SteffenFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Irena B KingFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Barbara McKnightFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Bruce M PsatyFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Luc DjousséFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Ida Y-D ChenFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Jason H Y WuFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
David S SiscovickFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Paul M RidkerFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Michael Y TsaiFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Eric B RimmFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Frank B HuFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Donna K ArnettFrom the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Cardiovascular Medicine (DM and PMR), Genetics (DIC), Preventive Medicine (LW, DIC, AYC, and PMR), and Aging (LD) and the Channing Division of Network Medicine (DM, QS, EBR, FBH), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Departments of Epidemiology (DM, EBR, and FBH) and Nutrition (DM, QS, H Wu, MKJ, EBR, and FBH), Harvard School of Public Health, Boston, MA; the Department of Medicine (COJ, RNL, BMP, and DSS), School of Medicine, and the Departments of Biostatistics (BM), Epidemiology (DSS and BMP), and Health Services (BMP), School of Public Health, University of Washington, Seattle, WA; the Group Health Collaborative Research Institute, Seattle, WA (BMP); Center for Public Health Genomics (AM and SSR) and the Division of Biostatistics (AM), Department of Public Health Sciences, University of Virginia, Charlottesville, VA; the Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (EKK); the Division of Epidemiology & Community Health, School of Public Health (LS) and Department of Laboratory Medicine & Pathology (MYT), University of Minnesota, Minneapolis, MN; Institute of Molecular Medicine (M Foy and M Fornage) and Division of Epidemiology (M Fornage), Human Genetics, and Environmental Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX; Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA (IY-DC); The George Institute for Global Health, University of Sydney, Australia (JHYW); and the Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL (H Wiener, MRI, and DKA).
Tufts University · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Genetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Genomewide Association Study of Lipid Response to Fenofibrate and Dietary FatR01HL091357 · NHLBI · UNIVERSITY OF KENTUCKY · PI ARNETT, DONNA K · 2008 to 2018
$5.8M
Fatty Acids and Major Cardiovascular OutcomesR01HL085710 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MOZAFFARIAN, DARIUSH · 2006 to 2016
$5.1M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
Vitamin D Status, Vitamin D Receptor Gene Variants, and Hypertension RiskR00HL095649 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, LU · 2012 to 2014
$729k
NCATS NIH HHS UL1 TR000124NCI NIH HHS UM1 CA182913NHLBI NIH HHS HL105756NHLBI NIH HHS R00-HL095649NHLBI NIH HHS R01 HL085710NHLBI NIH HHS R01 HL091357NHLBI NIH HHS U01 HL072524NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

backgroundCirculating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent influences (e.g., relating to incorporation, metabolism, or intercompetition with other fatty acids) that could alter circulating concentrations and possibly modulate or mediate impacts on health.

objectiveThe objective was to elucidate novel biologic pathways that may influence circulating TFAs by evaluating associations between common genetic variation and TFA biomarkers.

designWe performed meta-analyses using 7 cohorts of European-ancestry participants (n = 8013) having measured genome-wide variation in single-nucleotide polymorphisms (SNPs) and circulating TFA biomarkers (erythrocyte or plasma phospholipids), including trans-16:1n-7, total trans-18:1, trans/cis-18:2, cis/trans-18:2, and trans/trans-18:2. We further evaluated SNPs with genome-wide significant associations among African Americans (n = 1082), Chinese Americans (n = 669), and Hispanic Americans (n = 657) from 2 of these cohorts.

resultsAmong European-ancestry participants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with cis/trans-18:2; a top hit was rs174548 (β = 0.0035, P = 4.90 × 10(-15)), an SNP previously associated with circulating n-3 and n-6 polyunsaturated fatty acid concentrations. No significant association was identified for other TFAs. rs174548 in FADS1/2 was also associated with cis/trans-18:2 in Hispanic Americans (β = 0.0053, P = 1.05 × 10(-6)) and Chinese Americans (β = 0.0028, P = 0.002) but not African Americans (β = 0.0009, P = 0.34); however, in African Americans, fine mapping identified a top hit in FADS2 associated with cis/trans-18:2 (rs174579: β = 0.0118, P = 4.05 × 10(-5)). The association between rs174548 and cis/trans-18:2 remained significant after further adjustment for individual circulating n-3 and n-6 fatty acids, except arachidonic acid. After adjustment for arachidonic acid concentrations, the association between rs174548 and cis/trans-18:2 was nearly eliminated in European-ancestry participants (β-coefficient reduced by 86%), with similar reductions in Hispanic Americans and Chinese Americans.

conclusionsOur findings provide novel evidence for genetic regulation of cis/trans-18:2 by the FADS1/2 cluster and suggest that this regulation may be influenced/mediated by concentrations of arachidonic acid, an n-6 polyunsaturated fat.

Indexed as

Genetic LociArachidonic AcidAsianBiomarkersBlack or African AmericanDelta-5 Fatty Acid DesaturaseFatty Acids, Omega-6Gene FrequencyGenetic Association StudiesGenotyping TechniquesHumansPhospholipidsPolymorphism, Single NucleotideTrans Fatty AcidsWhite PeopleArachidonic AcidBiomarkersDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acids, Omega-6PhospholipidsTrans Fatty Acidsarachidonic acidgenome-wide associationmeta-analysisphospholipidtrans fatty acids

Identifiers

PMID25646338
PMCPMC4307209
OpenAlexW1963915610

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