Evidence map›Paper›PMID 25646333›Full record

ArticleThe American journal of clinical nutrition2015

Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts.

Raphaëlle Varraso, R Graham Barr, Walter C Willett, Frank E Speizer, Carlos A Camargo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  16. Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction.American journal of respiratory and critical care medicine · 2023
    Article
  17. The Protective Effect of Omega-3 Fatty Acids in Attenuating Lung Function Decline.American journal of respiratory and critical care medicine · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Raphaëlle VarrasoFrom the Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, France (RV); the Université Paris-Sud 11, UMRS 1018, Villejuif, France (RV); the Division of General Medicine, Departments of Medicine and of Epidemiology, Columbia University Medical Center, New York, NY (RGB); the Departments of Nutrition (WCW) and Epidemiology (WCW and CAC), Harvard School of Public Health, Boston, MA; the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (WCW, FES, and CAC); and the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA (CAC).
R Graham BarrFrom the Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, France (RV); the Université Paris-Sud 11, UMRS 1018, Villejuif, France (RV); the Division of General Medicine, Departments of Medicine and of Epidemiology, Columbia University Medical Center, New York, NY (RGB); the Departments of Nutrition (WCW) and Epidemiology (WCW and CAC), Harvard School of Public Health, Boston, MA; the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (WCW, FES, and CAC); and the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA (CAC).
Walter C WillettFrom the Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, France (RV); the Université Paris-Sud 11, UMRS 1018, Villejuif, France (RV); the Division of General Medicine, Departments of Medicine and of Epidemiology, Columbia University Medical Center, New York, NY (RGB); the Departments of Nutrition (WCW) and Epidemiology (WCW and CAC), Harvard School of Public Health, Boston, MA; the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (WCW, FES, and CAC); and the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA (CAC).
Frank E SpeizerFrom the Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, France (RV); the Université Paris-Sud 11, UMRS 1018, Villejuif, France (RV); the Division of General Medicine, Departments of Medicine and of Epidemiology, Columbia University Medical Center, New York, NY (RGB); the Departments of Nutrition (WCW) and Epidemiology (WCW and CAC), Harvard School of Public Health, Boston, MA; the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (WCW, FES, and CAC); and the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA (CAC).
Carlos A CamargoFrom the Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology team, Villejuif, France (RV); the Université Paris-Sud 11, UMRS 1018, Villejuif, France (RV); the Division of General Medicine, Departments of Medicine and of Epidemiology, Columbia University Medical Center, New York, NY (RGB); the Departments of Nutrition (WCW) and Epidemiology (WCW and CAC), Harvard School of Public Health, Boston, MA; the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (WCW, FES, and CAC); and the Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA (CAC).
Harvard University · USCentre de recherche en Epidémiologie et Santé des Populations · FRColumbia University Irving Medical Center · USUniversité Paris-Sud · FR

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Fish Oil Intake, Biomarkers and Change in Lung FunctionR01HL075476 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARR, R GRAHAM · 2004 to 2008
$2.8M
DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASER01HL063841 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CAMARGO, CARLOS A. · 2000 to 2002
$1.0M
Hormonal and Inflammatory Markers in Adult-onset AsthmaR21AI052338 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI CAMARGO, CARLOS A. · 2003 to 2003
$304k
NCI NIH HHS CA-167552NCI NIH HHS CA-87969NHLBI NIH HHS HL-63841NHLBI NIH HHS R01 HL075476NIAID NIH HHS AI-52338NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

backgroundDespite mechanistic data that linked fish and omega-3 (n-3) PUFAs with lower risk of chronic obstructive pulmonary disease (COPD), epidemiologic data remain scarce. Fish and n-3 PUFAs are an important component of the prudent dietary pattern that is thought to be protective in the onset of COPD.

objectiveWe examined the role of fish and PUFA intakes on risk of developing COPD while taking into account the overall dietary pattern.

designWe investigated the objective in 120,175 women and men from the Nurses' Health Study and Health Professionals Follow-Up Study. Over the study period (1984-2000), there were 889 cases of newly diagnosed COPD. Cumulative average intakes of fish, eicosapentaenoic acid, docosahexaenoic acid, n-3 PUFAs, n-6 PUFAs, and the n-3:n-6 ratio were calculated from repeated food-frequency questionnaires. Because fish is a food group included in the prudent pattern, we derived a new prudent pattern without the contribution from fish, and we termed this pattern the "modified prudent" pattern. We performed multivariable Cox proportional hazards models.

resultsBefore the dietary pattern was taken into account, and with 14 factors controlled for, we showed that more-frequent fish intake (≥4 servings/wk) was inversely associated with risk of COPD [adjusted pooled HR for the highest intake compared with the lowest intake (<1 serving/wk): 0.71; 95% CI: 0.54, 0.94]. After additional adjustment for the dietary pattern (modified prudent and Western patterns), the association was NS (0.84; 95% CI: 0.63, 1.13). No significant associations were shown between PUFA intakes and risk of COPD.

conclusionAlthough COPD-prevention efforts should continue to focus on smoking cessation, these prospective findings support the importance of promoting a healthy diet in multi-interventional programs to prevent COPD instead of focusing on changes in an isolated food or nutrient.

Indexed as

Feeding BehaviorSeafoodAdultAgedAnimalsDietDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3FemaleFishesFollow-Up StudiesHumansMaleMiddle AgedNutrition AssessmentDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3dietdietary patternsepidemiologyfishrespiratory diseases

Identifiers

PMID25646333
PMCPMC4307205
OpenAlexW2035008719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.