ArticlePlant physiology2015
The fragile Fiber1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- Gene regulatory and co-expression networks reveal novel hub genes and regulatory mechanisms in rapeseed (Brassica napus L.) under drought stress.Scientific reports · 2025Pooled it
- A grass-specific structural myosin VIII regulates protoxylem development and hydraulic conductance in sorghum.Plant physiology · 2026Article
- PEK14: A Kinesin-4 Necessary for Male-Derived Fertility in Arabidopsis thaliana.Cytoskeleton (Hoboken, N.J.) · 2026Article
- FE-SEM visualization of cortical microtubules in plant cells using freeze-fracture techniques.Plant methods · 2026Article
- Cytoskeletal control of development and environmental adaptation in plants.Science China. Life sciences · 2026Review
- N-terminal phosphorylation inhibits Arabidopsis katanin and affects vegetative and reproductive development in opposite ways.bioRxiv : the preprint server for biology · 2026Article
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- The epidermis coordinates multi-scale symmetry breaking in chiral root growth.Nature communications · 2025Article
- E69K mutation in β-tubulin 2 blocks cell wall integrity signaling during plant cell elongation.EMBO reports · 2025Article
- A MYB61-SWB9-KOs module regulates grain chalkiness via gibberellin biosynthesis in rice endosperm.Plant biotechnology journal · 2025Article
- Decoding the role of microtubules: a trafficking road for vesicle.Theranostics · 2025Review
- A divergent tumor overexpressed gene domain and oligomerization contribute to SPIRAL2 function in stabilizing microtubule minus ends.The Plant cell · 2024Article
- Cell wall anisotropy plays a key role in Zea mays stomatal complex movement: the possible role of the cell wall matrix.Plant molecular biology · 2023Article
- QTG-Miner aids rapid dissection of the genetic base of tassel branch number in maize.Nature communications · 2023Article
- Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella.Nature plants · 2023Article
- Brassinosteroid signals cooperate with katanin-mediated microtubule severing to control stamen filament elongation.The EMBO journal · 2023Article
- Detecting the orientation of newly-deposited crystalline cellulose with fluorescent CBM3.Cell surface (Amsterdam, Netherlands) · 2022Article
- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress.BMC plant biology · 2022Article
- Biochemical and cytological interactions between callose synthase and microtubules in the tobacco pollen tube.Plant cell reports · 2022Article
- Transcriptome analysis reveals the mechanism of internode development affecting maize stalk strength.BMC plant biology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell wall consists of cellulose microfibrils embedded within a matrix of hemicellulose and pectin. Cellulose microfibrils are synthesized at the plasma membrane, whereas matrix polysaccharides are synthesized in the Golgi apparatus and secreted. The trafficking of vesicles containing cell wall components is thought to depend on actin-myosin. Here, we implicate microtubules in this process through studies of the kinesin-4 family member, Fragile Fiber1 (FRA1). In an fra1-5 knockout mutant, the expansion rate of the inflorescence stem is halved compared with the wild type along with the thickness of both primary and secondary cell walls. Nevertheless, cell walls in fra1-5 have an essentially unaltered composition and ultrastructure. A functional triple green fluorescent protein-tagged FRA1 fusion protein moves processively along cortical microtubules, and its abundance and motile density correlate with growth rate. Motility of FRA1 and cellulose synthase complexes is independent, indicating that FRA1 is not directly involved in cellulose biosynthesis; however, the secretion rate of fucose-alkyne-labeled pectin is greatly decreased in fra1-5, and the mutant has Golgi bodies with fewer cisternae and enlarged vesicles. Based on our results, we propose that FRA1 contributes to cell wall production by transporting Golgi-derived vesicles along cortical microtubules for secretion.
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