Evidence map›Paper›PMID 25646258›Full record

ArticleThe American journal of tropical medicine and hygiene2015

Artemisinin resistance-associated polymorphisms at the K13-propeller locus are absent in Plasmodium falciparum isolates from Haiti.

Tamar E Carter, Alexis Boulter, Alexandre Existe, Jean R Romain, Jean Yves St Victor, Connie J Mulligan, Bernard A Okech

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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  4. Establishing a National Molecular Surveillance Program for the Detection ofThe American journal of tropical medicine and hygiene · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tamar E CarterGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida tamarec@ufl.edu.
Alexis BoulterGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.
Alexandre ExisteGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.
Jean R RomainGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.
Jean Yves St VictorGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.
Connie J MulliganGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.
Bernard A OkechGenetics and Genomics Program, University of Florida, Gainesville, Florida; Department of Anthropology, University of Florida, Gainesville, Florida; Genetics Institute, University of Florida, Gainesville, Florida; National Public Health Laboratory, Ministry of Public Health and the Population, Port-au-Prince, Haiti; Hospital Saint Croix, Leogane, Haiti; Blanchard Clinic, Terre Noire, Haiti; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Department of Environmental and Global Health, University of Florida, Gainesville, Florida.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimalarial drugs are a key tool in malaria elimination programs. With the emergence of artemisinin resistance in southeast Asia, an effort to identify molecular markers for surveillance of resistant malaria parasites is underway. Non-synonymous mutations in the kelch propeller domain (K13-propeller) in Plasmodium falciparum have been associated with artemisinin resistance in samples from southeast Asia, but additional studies are needed to characterize this locus in other P. falciparum populations with different levels of artemisinin use. Here, we sequenced the K13-propeller locus in 82 samples from Haiti, where limited government oversight of non-governmental organizations may have resulted in low-level use of artemisinin-based combination therapies. We detected a single-nucleotide polymorphism (SNP) at nucleotide 1,359 in a single isolate. Our results contribute to our understanding of the global genomic diversity of the K13-propeller locus in P. falciparum populations.

Indexed as

Drug ResistancePolymorphism, GeneticAntimalarialsArtemisininsHaitiHumansMalaria, FalciparumPlasmodium falciparumAntimalarialsartemisininArtemisinins

Identifiers

PMID25646258
PMCPMC4350547

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.