Evidence map›Paper›PMID 25645971›Full record

ArticleNature reviews. Gastroenterology & hepatology2015

Developmental biology. Regional identity of gut stem cells--one gene to rule them all.

James M Wells

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature reviews. Gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Plasticity in the lung: making and breaking cell identity.Development (Cambridge, England) · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James M WellsDivision of Developmental Biology and Division of Endocrinology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.
Cincinnati Children's Hospital Medical Center · US

Funding

Intestinal Stem Cell Consortium Coordinating CenterU01DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2009 to 2018
$6.5M
Investigation of Regional Identity in Human Intestinal Stem CellsU01DK103117 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HELMRATH, MICHAEL A. · 2014 to 2023
$4.0M
Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating CenterU24DK085532 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2019 to 2023
$2.3M
Human Endocrine Cell DevelopmentR01DK092456 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI WELLS, JAMES M · 2012 to 2016
$2.3M
Single Cell/RNA-Seq dissection of Human iPS cell development into intestineR01DK098350 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WELLS, JAMES M · 2013 to 2016
$1.3M
Generating Human Intestinal Organoids with an ENS.U18TR000546 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI WELLS, JAMES M · 2012 to 2014
$905k
NCATS NIH HHS U18 TR000546NIDDK NIH HHS R01 DK092456NIDDK NIH HHS R01 DK098350NIDDK NIH HHS U01 DK085532NIDDK NIH HHS U01 DK103117NIDDK NIH HHS U24 DK085532
6 · The paper itself

Abstract

The stem cells in the stomach and intestine are regulated by different signalling pathways and give rise to entirely different specialized lineages. A study by Simmini and colleagues suggests that the organ-specific identity of gastrointestinal stem cells is regulated by one transcription factor, Cdx2.

Indexed as

AnimalsCellular ReprogrammingFemaleGastric MucosaHomeodomain ProteinsIntestinal MucosaMaleSpheroids, CellularStem CellsTranscription FactorsHomeodomain ProteinsTranscription Factors

Identifiers

PMID25645971
OpenAlexW2087227890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.