ArticleDevelopmental biology2015
miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Cannabidiol-Loaded Retinal Organoid-Derived Extracellular Vesicles Protect Oxidatively Stressed ARPE-19 Cells.Biomedicines · 2025Article
- miRNA changes associated with differentiation of human embryonic stem cells into human retinal ganglion cells.Scientific reports · 2024Article
- An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis.JCI insight · 2023Article
- MicroRNAs in the Mouse Developing Retina.International journal of molecular sciences · 2023Review
- Non-coding RNAs targeting NF-κB pathways in aquatic animals: A review.Frontiers in immunology · 2023Review
- Regulation of retinal amacrine cell generation by miR-216b and Foxn3.Development (Cambridge, England) · 2022Article
- LncRNA MALAT1 promotes proliferation and migration of airway smooth muscle cells in asthma by downregulating microRNA-216a.Saudi journal of biological sciences · 2021Article
- miRNAs and Müller Glia Reprogramming During Retina Regeneration.Frontiers in cell and developmental biology · 2020Review
- Sorting Nexin 5 Controls Head and Neck Squamous Cell Carcinoma Progression by Modulating FBW7.Journal of Cancer · 2019Article
- Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injuryJournal of biosciences · 2018Article
- miRNAexpression profile of retinal pigment epithelial cells under oxidative stress conditions.FEBS open bio · 2018Article
- Physiological response and microRNA expression profiles in head kidney of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) exposed to acute cold stress.Scientific reports · 2018Article
- MiR-211 is essential for adult cone photoreceptor maintenance and visual function.Scientific reports · 2017Article
- The Regulation of Notch Signaling in Retinal Development and Regeneration.Current pathobiology reports · 2017Article
- miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development.Developmental biology · 2017Article
- Functional dissection of human targets for KSHV-encoded miRNAs using network analysis.Scientific reports · 2017Article
- Neurotransmitter-Regulated Regeneration in the Zebrafish Retina.Stem cell reports · 2017Article
- Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development.Molecules and cells · 2017Article
- High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs.Nucleic acids research · 2016Article
- Systematic Identification and Bioinformatic Analysis of MicroRNAs in Response to Infections of Coxsackievirus A16 and Enterovirus 71.BioMed research international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Precise regulation of Notch signaling is essential for normal vertebrate development. Mind bomb (Mib) is a ubiquitin ligase that is required for activation of Notch by Notch׳s ligand, Delta. Sorting Nexin 5 (SNX5) co-localizes with Mib and Delta complexes and has been shown to directly bind to Mib. We show that microRNA-216a (miR-216a) is expressed in the retina during early development and regulates snx5 to precisely regulate Notch signaling. miR-216a and snx5 have complementary expression patterns. Knocking down miR-216a and/or overexpression of snx5 resulted in increased Notch activation. Conversely, knocking down snx5 and/or miR-216a overexpression caused a decrease in Notch activation. We propose a model in which SNX5, precisely controlled by miR-216a, is a vital partner of Mib in promoting endocytosis of Delta and subsequent activation of Notch signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.