Trial reportJournal of the American Geriatrics Society2015
Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants.
Trial report in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of an exercise program using an smatphone App with remote or in-person supervision on the functional capacity of older adults: a randomized clinical.Einstein (Sao Paulo, Brazil) · 2026Trial
- The association between metabolic syndrome and successful aging- using an extended definition of successful aging.PloS one · 2021Trial
- Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial.Obesity (Silver Spring, Md.) · 2017Trial
- Does Lifestyle Exercise After a Cardiac Event Improve Metabolic Syndrome Profile in Older Adults?The Journal of cardiovascular nursingTrial
- Blood pressure and the risk of diabetes: A longitudinal observational study based on Chinese individuals.Journal of diabetes investigation · 2025Observational
- Can self-rated health be useful to primary care physicians as a diagnostic indicator of metabolic dysregulations amongst patients with type 2 diabetes? A population-based study.BMC primary care · 2025Article
- Association of metabolic syndrome components and their combinations with functional disability among older adults in a longevity-associated ethnic minority region of Southwest China.Frontiers in public health · 2025Article
- Relationship of Inflammatory Markers and Metabolic Syndrome in Postmenopausal Women.Metabolites · 2022Article
- Changes in metabolic syndrome affect the health-related quality of life of community-dwelling adults.Scientific reports · 2021Article
- Muscle mass rather than muscle strength or physical performance is associated with metabolic syndrome in community-dwelling older Chinese adults.BMC geriatrics · 2021Article
- Innovations in Geroscience to enhance mobility in older adults.Experimental gerontology · 2020Review
- Impact of Self-Rated Health on Progression to a Metabolically Unhealthy Phenotype in Metabolically Healthy Obese and Non-Obese Individuals.Journal of clinical medicine · 2019Article
- Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management.Pharmacology & therapeutics · 2018Review
- Circulating MicroRNA Are Predictive of Aging and Acute Adaptive Response to Resistance Exercise in Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate.Canadian journal of physiology and pharmacology · 2017Article
- Phosphorylation of Histone H2A.X in Peripheral Blood Mononuclear Cells May Be a Useful Marker for Monitoring Cardiometabolic Risk in Nondiabetic Individuals.Disease markers · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the prevalence of metabolic syndrome (MetS) and its association with physical capacity, disability, and self-rated health in older adults at high risk of mobility disability, including those with and without diabetes mellitus.
designCross-sectional analysis.
settingLifestyle Interventions and Independence for Elders (LIFE) Study.
participantsCommunity-dwelling sedentary adults aged 70 to 89 at high risk of mobility disability (Short Physical Performance Battery (SPPB) score ≤9; mean 7.4 ± 1.6) (N = 1,535). MEASUREMENTS: Metabolic syndrome was defined according to the 2009 multiagency harmonized criteria; outcomes were physical capacity (400-m walk time, grip strength, SPPB score), disability (composite 19-item score), and self-rated health (5-point scale ranging from excellent to poor).
resultsThe prevalence of MetS was 49.8% in the overall sample (83.2% of those with diabetes mellitus, 38.1% of those without). MetS was associated with stronger grip strength (mean difference (Δ) = 1.2 kg, P = .01) in the overall sample and in participants without diabetes mellitus and with poorer self-rated health (Δ = 0.1 kg, P < .001) in the overall sample only. No significant differences were found in 400-m walk time, SPPB score, or disability score between participants with and without MetS, in the overall sample or diabetes mellitus subgroups.
conclusionMetabolic dysfunction is highly prevalent in older adults at risk of mobility disability, yet consistent associations were not observed between MetS and walking speed, lower extremity function, or self-reported disability after adjusting for known and potential confounders. Longitudinal studies are needed to investigate whether MetS accelerates declines in functional status in high-risk older adults and to inform clinical and public health interventions aimed at preventing or delaying disability in this group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.