ArticleCNS neuroscience & therapeutics2015
Leptin: a potential anxiolytic by facilitation of fear extinction.
Article in CNS neuroscience & therapeutics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Low Levels of Serum Ghrelin and Nesfatin-1 Are Associated With Anxiety Disorders in Children.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2025Article
- NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex.Frontiers in behavioral neuroscience · 2025Article
- Leptin excites basolateral amygdala principal neurons and reduces food intake by LepRb-JAK2-PI3K-dependent depression of GIRK channels.Journal of cellular physiology · 2024Article
- Defensive responses: behaviour, the brain and the body.Nature reviews. Neuroscience · 2023Review
- The potential effect mechanism of high-fat and high-carbohydrate diet-induced obesity on anxiety and offspring of zebrafish.Eating and weight disorders : EWD · 2022Article
- N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis.Acta pharmacologica Sinica · 2022Article
- Restlessness and an Increased Urge to Move (Drive for Activity) in Anorexia Nervosa May Strengthen Personal Motivation to Maintain Caloric Restriction and May Augment Body Awareness and Proprioception: A Lesson From Leptin Administration in Anorexia Nervosa.Frontiers in psychology · 2022Review
- Leptin polymorphism rs3828942: risk for anxiety disorders?European archives of psychiatry and clinical neuroscience · 2021Article
- Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults.Scientific reports · 2021Article
- Identification of the Similarities and Differences of Molecular Networks Associated With Fear Memory Formation, Extinction, and Updating in the Amygdala.Frontiers in molecular neuroscience · 2021Article
- Structural and functional consequences in the amygdala of leptin-deficient mice.Cell and tissue research · 2020Article
- Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y.Annals of the New York Academy of Sciences · 2019Review
- Relationship Between White Matter Integrity and Plasma Leptin Levels in Drug-Naïve and Medicated Patients With Major Depressive Disorder.Frontiers in neuroscience · 2019Article
- Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.International journal of molecular sciences · 2018Article
- Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease.Frontiers in cellular neuroscience · 2018Review
- Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward.Translational psychiatry · 2016Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAnxiety disorders are characterized by a deficient extinction of fear memory. Evidence is growing that leptin influences numerous neuronal functions. The aims of this study were to investigate the effects and the mechanism of leptin on fear extinction. METHODS AND
resultsLeptin (1 mg/kg, i.p) was applied to evaluate the anxiolytic effect in rat behavioral tests. Field potentials recording were used to investigate the changes in synaptic transmission in the thalamic-lateral amygadala (LA) pathway of rat. We found that leptin produced strong anxiolytic effects under basal condition and after acute stress. Systemic administration and intra-LA infusions of leptin facilitated extinction of conditioned fear responses. The antagonist of NMDA receptor, MK-801, blocked the effect of leptin on fear extinction completely. Furthermore, these effects of leptin on fear extinction were accompanied by a reversal of conditioning-induced synaptic potentiation in the LA. Leptin facilitated NMDA receptor-mediated synaptic transmission, and reversed amygdala long-term potentiation (LTP) in a dose-dependent manner in vitro, and this LTP depotentiation effect was mediated by NMDA receptor and MAPK signaling pathway.
conclusionsThese results identify a key role of leptin in dampening fear conditioning-induced synaptic potentiation in the LA through NMDA receptor and indicate a new strategy for treating anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.