ArticleAngewandte Chemie (International ed. in English)2015
Hydrogen-bonding interactions trigger a spin-flip in iron(III) porphyrin complexes.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- π-Conjugation Mediates Competing J12 and J13 Interactions at the Nanometric Scale in Linear Fe(III) Porphyrin Trimers.Inorganic chemistry · 2026Article
- Redox and Spin States Series of an Organometallic Heme Analogue Based on a Non-Innocent NHC/N-Donor Hybrid Macrocycle.Inorganic chemistry · 2026Article
- Enhanced Reactivities of Iron(IV)-Oxo Porphyrin Species in Oxidation Reactions Promoted by Intramolecular Hydrogen-Bonding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Breaking a Molecular Scaling Relationship Using an Iron-Iron Fused Porphyrin Electrocatalyst for Oxygen Reduction.Journal of the American Chemical Society · 2024Article
- Heme-copper and Heme OJournal of inorganic biochemistry · 2023Review
- Iron(III)-based metalloradical catalysis for asymmetric cyclopropanation via a stepwise radical mechanism.Nature chemistry · 2023Article
- Reversible thermally induced spin crossover in the myoglobin-nitrito adduct directly monitored by resonance Raman spectroscopy.RSC advances · 2023Article
- Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents.Molecules (Basel, Switzerland) · 2022Review
- Electrostatic Perturbations in the Substrate-Binding Pocket of Taurine/α-Ketoglutarate Dioxygenase Determine its Selectivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Proton mediated spin state transition of cobalt heme analogs.Nature communications · 2019Article
- Spin Interconversion of Heme-Peroxo-Copper Complexes Facilitated by Intramolecular Hydrogen-Bonding Interactions.Journal of the American Chemical Society · 2019Article
- Bridging the Homogeneous-Heterogeneous Divide: Modeling Spin for Reactivity in Single Atom Catalysis.Frontiers in chemistry · 2019Article
- Advances in Sustainable Catalysis: A Computational Perspective.Frontiers in chemistry · 2019Review
- Light-controlled switching of the spin state of iron(III).Nature communications · 2018Article
- Ground State and Excited State Tuning in Ferric Dipyrrin Complexes Promoted by Ancillary Ligand Exchange.Inorganic chemistry · 2017Article
- Challenging Density Functional Theory Calculations with Hemes and Porphyrins.International journal of molecular sciences · 2016Review
- Oxidation triggers extensive conjugation and unusual stabilization of two di-heme dication diradical intermediates: role of bridging group for electronic communication.Chemical science · 2016Article
- All high-spin (S = 2) iron(ii) hemes are NOT alike.Dalton transactions (Cambridge, England : 2003) · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A key step in cytochrome P450 catalysis includes the spin-state crossing from low spin to high spin upon substrate binding and subsequent reduction of the heme. Clearly, a weak perturbation in P450 enzymes triggers a spin-state crossing. However, the origin of the process whereby enzymes reorganize their active site through external perturbations, such as hydrogen bonding, is still poorly understood. We have thus studied the impact of hydrogen-bonding interactions on the electronic structure of a five-coordinate iron(III) octaethyltetraarylporphyrin chloride. The spin state of the metal was found to switch reversibly between high (S=5/2) and intermediate spin (S=3/2) with hydrogen bonding. Our study highlights the possible effects and importance of hydrogen-bonding interactions in heme proteins. This is the first example of a synthetic iron(III) complex that can reversibly change its spin state between a high and an intermediate state through weak external perturbations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.