Evidence map›Paper›PMID 25645574›Full record

GuidelineThe American journal of gastroenterology2015

ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.

Sapna Syngal, Randall E Brand, James M Church, Francis M Giardiello, Heather L Hampel, Randall W Burt, American College of Gastroenterology

Registry-linked trialAbstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The American journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06330441 (Pancreatic Cancer Screening in a Population at High Risk), which is not on this map. Cited by 672 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
672citing papers in PubMed, 6 pooled it
94.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06330441 narecruitingnot on this mapstarted 2022, after this paper: background citation

Pancreatic Cancer Screening in a Population at High Risk

TypeinterventionalSponsorMasaryk Memorial Cancer InstituteRan2022 to 2028Enrolled700ConditionsPancreatic Ductal Adenocarcinoma, Hereditary Diseases, Pancreatitis, ChronicArmsendoscopic ultrasonography, magnetic resonance, laboratory examination
3 · Its place in the literature

Who cites it

672 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,593 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Guideline
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. A Case of Gastric Juvenile-Type Polyposis With SMAD4 Mutation.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Article
  14. Article
  15. Emerging trends in the global burden of colorectal cancer.Nature reviews. Clinical oncology · 2026
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Gastric Adenomas and Mimickers: A Review.Diagnostics (Basel, Switzerland) · 2026
    Review

612 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Sapna Syngal1] Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Dana Farber Cancer Institute, Boston, Massachusetts, USA [3] Harvard Medical School, Boston, Massachusetts, USA.
Randall E BrandDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
James M Church1] Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA [2] Sanford R Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio, USA [3] Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Francis M GiardielloJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Heather L HampelDepartment of Internal Medicine, Ohio State University, Columbus, Ohio, USA.
Randall W BurtHuntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
American College of Gastroenterology
Cleveland Clinic · USHarvard University · USJohns Hopkins Medicine · USThe Ohio State University · USUniversity of Pittsburgh Medical Center · USUniversity of Utah · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973PHS HHS K24-11311
6 · The paper itself

Abstract

This guideline presents recommendations for the management of patients with hereditary gastrointestinal cancer syndromes. The initial assessment is the collection of a family history of cancers and premalignant gastrointestinal conditions and should provide enough information to develop a preliminary determination of the risk of a familial predisposition to cancer. Age at diagnosis and lineage (maternal and/or paternal) should be documented for all diagnoses, especially in first- and second-degree relatives. When indicated, genetic testing for a germline mutation should be done on the most informative candidate(s) identified through the family history evaluation and/or tumor analysis to confirm a diagnosis and allow for predictive testing of at-risk relatives. Genetic testing should be conducted in the context of pre- and post-test genetic counseling to ensure the patient's informed decision making. Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers. This guideline specifically discusses genetic testing and management of Lynch syndrome, familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), Peutz-Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, serrated (hyperplastic) polyposis syndrome, hereditary pancreatic cancer, and hereditary gastric cancer.

Indexed as

Adenomatous Polyposis ColiColorectal Neoplasms, Hereditary NonpolyposisDisease ManagementGastrointestinal NeoplasmsGenetic TestingHamartoma Syndrome, MultipleHumansIntestinal PolyposisNeoplastic Syndromes, HereditaryPeutz-Jeghers Syndrome

Identifiers

PMID25645574
PMCPMC4695986
OpenAlexW2162077547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.