ArticleCurrent protocols in toxicology2015
Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures.
Article in Current protocols in toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Systematic optimization of a domestic nose-only aerosol exposure system for respiratory pathogen research in nonhuman primates.Biosafety and health · 2026Article
- Evaluation of the toxicity of combustion smokes at the air-liquid interface: a comparison between two lung cell models and two exposure methods.Archives of toxicology · 2025Article
- Navigating the Development of Dry Powder for Inhalation: A CDMO Perspective.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Inhalation of electronic cigarettes slightly affects lung function and inflammation in mice.Frontiers in toxicology · 2023Article
- Gestational exposure to titanium dioxide, diesel exhaust, and concentrated urban air particles affects levels of specialized pro-resolving mediators in response to allergen in asthma-susceptible neonate lungs.Journal of toxicology and environmental health. Part A · 2022Article
- Air pollution and children's health-a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter.Environmental health and preventive medicine · 2021Review
- Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction.Journal of visualized experiments : JoVE · 2020Article
- Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats.Journal of toxicologic pathology · 2020Article
- Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration.Particle and fibre toxicology · 2019Article
- Development of a large-scale computer-controlled ozone inhalation exposure system for rodents.Inhalation toxicology · 2019Article
- Settled iron-based road dust and its characteristics and possible association with detection in human tissues.Environmental science and pollution research international · 2019Article
- Acute Toxicity in the Rat Lung Induced by Intratracheal Instillation of Glycolic Acid.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In this unit, the need for laboratory-based inhalation toxicology studies, the historical background on adverse health effects of airborne toxicants, and the benefits of advance planning for the building of analytic options into the study design to maximize the scientific gains to be derived from the investments in the study are outlined. The following methods are described: (1) the generation and characterization of exposure atmospheres for inhalation exposures in humans and laboratory animals; (2) the delivery and distribution into and within whole-body exposure chambers, head-only exposure chambers, face-masks, and mouthpieces or nasal catheters; (3) options for on-line functional assays during and between exposures; and (4) options for serial non-invasive assays of response. In doing so, a description beyond exposures to single agents and simple mixtures is presented, and included are methods for evaluating biological responses to complex environmental mixtures. It is also emphasized that great care should be taken in the design and execution of such studies so that the scientific returns can be maximized both initially, and in follow-up utilization of archived samples of the exposure atmospheres, excreta, and tissues collected for histology.
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