ArticleThe Journal of antimicrobial chemotherapy2015
Novel gentamicin resistance genes in Campylobacter isolated from humans and retail meats in the USA.
Article in The Journal of antimicrobial chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
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- The Global Challenge ofTropical medicine and infectious disease · 2025Review
- The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance inAntimicrobial agents and chemotherapy · 2024Article
- The Transmission ofPathogens (Basel, Switzerland) · 2024Article
- Species Delineation and Comparative Genomics within theJournal of clinical microbiology · 2023Review
- Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Review
- Whole-Genome and Plasmid Comparative Analysis of Campylobacter jejuni from Human Patients in Toyama, Japan, from 2015 to 2019.Microbiology spectrum · 2023Article
- Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review.Journal of animal science and biotechnology · 2022Review
- The Enterotoxin Production and Antimicrobial Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Differences in the Propensity of Different Antimicrobial Resistance Determinants to Be Disseminated via Transformation inMicroorganisms · 2022Article
- Antimicrobial Resistance in Campylobacter coli and Campylobacter jejuni from Human Campylobacteriosis in Taiwan, 2016 to 2019.Antimicrobial agents and chemotherapy · 2022Article
- Microbiota from Specific Pathogen-Free Mice ReducesPathogens (Basel, Switzerland) · 2021Article
- Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Core Genome MLST for Source Attribution ofFrontiers in microbiology · 2021Article
- Resistance to Antibiotics in Thermophilic Campylobacters.Frontiers in medicine · 2021Review
- Aminoglycoside Resistance and Possible Mechanisms inFrontiers in microbiology · 2021Article
- Highly Prevalent Multidrug-ResistantFrontiers in microbiology · 2021Article
- Whole Resistome Analysis inFrontiers in microbiology · 2021Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo understand the molecular epidemiology of gentamicin-resistant Campylobacter and investigate aminoglycoside resistance mechanisms.
methodsOne-hundred-and-fifty-one gentamicin-resistant Campylobacter isolates from humans (n = 38 Campylobacter jejuni; n = 41, Campylobacter coli) and retail chickens (n = 72 C. coli), were screened for the presence of gentamicin resistance genes by PCR and subtyped using PFGE. A subset of the isolates (n = 41) was analysed using WGS.
resultsNine variants of gentamicin resistance genes were identified: aph(2″)-Ib, Ic, Ig, If, If1, If3, Ih, aac(6')-Ie/aph(2″)-Ia and aac(6')-Ie/aph(2″)-If2. The aph(2″)-Ib, Ic, If1, If3, Ih and aac(6')-Ie/aph(2″)-If2 variants were identified for the first time in Campylobacter. Human isolates showed more diverse aminoglycoside resistance genes than did retail chicken isolates, in which only aph(2″)-Ic and -Ig were identified. The aph(2″)-Ig gene was only gene shared by C. coli isolates from human (n = 27) and retail chicken (n = 69). These isolates displayed the same resistance profile and similar PFGE patterns, suggesting that contaminated retail chicken was probably the source of human C. coli infections. Human isolates were genetically diverse and generally more resistant than the retail chicken isolates. The most frequent co-resistance was to tetracycline (78/79, 98.7%), followed by ciprofloxacin/nalidixic acid (46/79, 58.2%), erythromycin and azithromycin (36/79, 45.6%), telithromycin (32/79, 40.5%) and clindamycin (18/79, 22.8%). All human and retail meat isolates were susceptible to florfenicol.
conclusionsThis study demonstrated that several new aminoglycoside resistance genes underlie the recent emergence of gentamicin-resistant Campylobacter, and that, in addition to contaminated retail chicken, other sources have also contributed to gentamicin-resistant Campylobacter infections in humans.
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