ArticleVaccine2015
Adolescent decision making about participation in a hypothetical HIV vaccine trial.
Article in Vaccine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Experiences and perspectives of children and adolescents participating in pediatric clinical trials: a qualitative evidence synthesis.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Missing assent: a global systematic review of ethical practices in HIV research with men who have sex with men (MSM) under 18.BMC medical ethics · 2026Pooled it
- Ethical Aspects of Involving Adolescents in HIV Research: A Systematic Review of the Empiric Literature.The Journal of pediatrics · 2023Pooled it
- Adolescent participation in HIV research: consortium experience in low and middle-income countries and scoping review.The lancet. HIV · 2020Pooled it
- Adolescent views on participating in HIV biomedical research during pregnancy: a qualitative analysis of motivators and barriers.AIDS care · 2026Article
- Decision-making for children and adolescents: a scoping review of interventions increasing participation in decision-making.Pediatric research · 2025Article
- The experience of trial participation disclosure among sex workers in a phase IIb HIV vaccine trial: A qualitative study in urban Tanzania.PLOS global public health · 2025Article
- How do we best engage young people in decision-making about their health? A scoping review of deliberative priority setting methods.International journal for equity in health · 2023Article
- "[T]he laws need to change to reflect current society": Insights from stakeholders involved in development, review or implementation of policies about adolescent consent for HIV testing, care and research in Kenya.Journal of the International AIDS Society · 2023Article
- "An Extra Variable to Consider"-Vaccine-Induced Seropositivity and Adolescent HIV Vaccine Clinical Trials.Journal of the Pediatric Infectious Diseases Society · 2022Article
- Competence to Consent to Oral and Injectable PrEP Trials Among Adolescent Males Who Have Sex with Males.AIDS and behavior · 2021Article
- Adolescent and Parent Perceptions about Participation in Biomedical Sexual Health Trials.Ethics & human research · 2020Article
- What motivates or demotivates injecting drug users to participate in hypothetical HIV vaccine efficacy trials? A qualitative study from urban Tanzania.The East African health research journal · 2020Article
- Avoiding a Tyranny of the Majority: Public Deliberation as Citizen Science, Sensitive Issues, and Vulnerable Populations.The American journal of bioethics : AJOB · 2019Article
- "I think the parent should be there because no one was born alone": Kenyan adolescents' perspectives on parental involvement in HIV research.African journal of AIDS research : AJAR · 2018Article
- Adolescent and Parent Willingness to Participate in Microbicide Safety Studies.Journal of pediatric and adolescent gynecology · 2017Article
- Adolescent Human Immunodeficiency Virus Care Providers' Attitudes Toward the Use of Oral Pre-Exposure Prophylaxis in Youth.AIDS patient care and STDs · 2016Article
- Self-Consent for HIV Prevention Research Involving Sexual and Gender Minority Youth: Reducing Barriers Through Evidence-Based Ethics.Journal of empirical research on human research ethics : JERHRE · 2016Article
- Contrasting Comprehension of HIV Research by Adolescents, Young Adults, and Caregivers in Western Kenya: A Cross-sectional Analysis.The Journal of the Association of Nurses in AIDS Care : JANACArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of this study was to examine the process of adolescent decision-making about participation in an HIV vaccine clinical trial, comparing it to adult models of informed consent with attention to developmental differences.
methodsAs part of a larger study of preventive misconception in adolescent HIV vaccine trials, we interviewed 33 male and female 16-19-year-olds who have sex with men. Participants underwent a simulated HIV vaccine trial consent process, and then completed a semistructured interview about their decision making process when deciding whether or not to enroll in and HIV vaccine trial. An ethnographic content analysis approach was utilized.
resultsTwelve concepts related to adolescents' decision-making about participation in an HIV vaccine trial were identified and mapped onto Appelbaum and Grisso's four components of decision making capacity including understanding of vaccines and how they work, the purpose of the study, trial procedures, and perceived trial risks and benefits, an appreciation of their own situation, the discussion and weighing of risks and benefits, discussing the need to consult with others about participation, motivations for participation, and their choice to participate.
conclusionThe results of this study suggest that most adolescents at high risk for HIV demonstrate the key abilities needed to make meaningful decisions about HIV vaccine clinical trial participation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.