ArticleObesity (Silver Spring, Md.)2015
Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus.Experimental physiology · 2024Trial
- Efficacy and safety of fixed-dose combination therapy, alogliptin plus metformin, in Asian patients with type 2 diabetes: A phase 3 trial.Diabetes, obesity & metabolism · 2017Trial
- A digital twin framework for predicting and simulating type 2 diabetes onset using retrospective lifestyle data.Frontiers in digital health · 2026Article
- Circulating FGF21 is lower in South Asians compared with Europids with type 2 diabetes mellitus.Endocrine connections · 2025Article
- Comparison of race- and ethnicity-specific BMI cutoffs for categorizing obesity severity: a multicountry prospective cohort study.Obesity (Silver Spring, Md.) · 2024Article
- Visceral-to-peripheral adiposity ratio: a critical determinant of sex and ethnic differences in cardiovascular risks among Asian Indians and African Creoles in Mauritius.International journal of obesity (2005) · 2024Article
- How do sex-specific BMI trajectories shape diabetes risk? A longitudinal analysis of Indonesian adults.BMJ public health · 2023Article
- Article
- Body composition and risk factors for cardiovascular disease in global multi-ethnic populations.International journal of obesity (2005) · 2023Article
- A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda.Journal of the Indian Institute of Science · 2023Review
- Article
- Body Fat Distribution, Glucose Metabolism, and Diabetes Status Among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study.Journal of epidemiology · 2022Article
- Carotid atherosclerosis in people of European, South Asian and African Caribbean ethnicity in the Southall and Brent revisited study (SABRE).Frontiers in cardiovascular medicine · 2022Article
- Risk factors, ethnicity and dementia: A UK Biobank prospective cohort study of White, South Asian and Black participants.PloS one · 2022Review
- A Genome-Wide Association Study on Abdominal Adiposity-Related Traits in Adult Korean Men.Obesity facts · 2022Article
- Visceral adiposity index outperforms conventional anthropometric assessments as predictor of diabetes mellitus in elderly Chinese: a population-based study.Nutrition & metabolism · 2021Article
- Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues.International journal of molecular sciences · 2021Review
- Ethnicity-specific BMI cutoffs for obesity based on type 2 diabetes risk in England: a population-based cohort study.The lancet. Diabetes & endocrinology · 2021Article
- The Obesity Paradox Predicts the Second Wave of COVID-19 to Be Severe in Western Countries.International journal of environmental research and public health · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo examine ethnic differences in ectopic fat and associations with incident diabetes.
methodsIn a UK cohort study, 1338 Europeans, 838 South Asians, and 330 African Caribbeans living in London were aged 40-69 years at baseline. Baseline assessment included blood tests, anthropometry, and questionnaires. Anthropometry-based prediction equations estimated baseline visceral adipose tissue (VAT). Incident diabetes was ascertained from record review, self-report, or oral glucose tolerance testing.
resultsSouth Asians had more and African Caribbeans less estimated VAT than Europeans. Both ethnic minorities had larger truncal skinfolds than Europeans. In men, adjustment for risk factors (BMI, smoking, systolic blood pressure, and HDL-cholesterol) markedly attenuated the association between estimated VAT and diabetes in Europeans (standardized subhazard ratios [95% CI]: from 1.74 [1.49, 2.03] to 1.16 [0.77, 1.76]) and African Caribbeans (1.72 [1.26, 2.35] to 1.44 [0.69, 3.02]) but not South Asians (1.60 [1.38, 1.86] to 1.90 [1.37, 2.64]). In women, attenuation was observed only for South Asians (1.80 [1.01, 3.23] to 1.07 [0.49, 2.31]). Associations between truncal skinfolds and diabetes appeared less affected by multivariable adjustment in South Asians and African Caribbeans than Europeans (1.24 [0.97, 1.57] and 1.28 [0.89, 1.82] versus 1.02 [0.77, 1.36] in men; 1.91 [1.03, 3.56] and 1.42 [0.86, 2.34] versus 1.23 [0.74, 2.05] in women).
conclusionsDifferences in overall truncal fat, as well as VAT, may contribute to the excess of diabetes in South Asian and African Caribbean groups, particularly for women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.